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Dalian Ding

Research Professor
Office: 137R Cary Hall
Office Phone: 716.829.5311
Email: dding@buffalo.edu

Education / Training:

1970-1973, Afterhours Nursing School, Wuhan Medical College, China

1986-1989, M.S., Department of Bioengineering, Fudan University, China

2011-2014, Ph.D., Department of Applied Biological Chemistry, University of Tokyo, Japan

 

Employment / Professional Experience:

1972-1978, Technician, Otologic Laboratory, Tongji Medical University, Wuhan, China
1979-1989, Chief Technician, Otologic Laboratory, Renji Hospital. Shanghai, China
1989-1991, Research Assistant, Otologic Laboratory, Shanghai Second Medical University. Shanghai, China
1991-1993, Assistant Research Fellow, Otologic Laboratory, Shanghai Second Medical University, Shanghai, China
1993-1995, Associate Research Professor, Otologic Laboratory, Shanghai Second Medical University. Shanghai, China
1995-2003, Assistant Research Professor, Center for Hearing and Deafness, University at Buffalo
2003-2007, Associate Research Professor, Center for Hearing and Deafness, University at Buffalo
2007-present, Research Professor, Department of Communicative Disorders and Science, University at Buffalo
2009-present, Research Professor, Department of Otolaryngology-Head and Neck Surgery, Third Xiangya Hospital of Central South University, China
2010-present, Doctoral Tutor and Professor, Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital of Central South University, China
2012-present, Research Professor, Department of Otorhinolaryngology, Third Affiliated Hospital, Sun Yat-sen University, China
2012-present, Research Professor, Guangxi Medical University, China

 

Professional Honors/ Advisory and Editorial Boards:

Honors and Awards
Excellent Thesis of Chinese Medical Association, 1982.
Scientific Progress of Chinese Military, (Grade 3), 1989.
Excellent Thesis of Chinese Medical Association, (Grade 3), 1989.
Shanghai Silver Snake Awards, 1991.
Significant Achievement on Scientific Research of Renji, 1992.
Shanghai Excellent Thesis, (Grade 3), 1993.
Winning Prize Award of Renji, 1993.
Enlisted in “Dictionary of Contemporary Chinese Scientists and Inventors”, 1994.
Excellent Thesis of Renji, (Grade 1), 1994.
Advanced Scientific Researcher of Renji, 1994.
Winning Prize Award of Renji, (Grade 1), 1994.
Scientific Progress of Chinese Educational Ministry, (Grade 3), 1995.
Scientific Achievement of Shanghai, 1995.
Scientific Achievement of Shanghai, 1996.
Promising Inventor Award of State University of New York. 2004

Editorial Board
Chinese Journal of Otorhinolaryngology, 1994-1998.
Chinese Journal of Otorhinolaryngology of Integrated Traditional and Western Medicine, 2001-present.
Chinese Journal of Otology, 2002-present.
Journal of Audiology and Speech Disorder, 2006-present.
Chinese Journal of Otorhinolaryngology-Skull Base Surgery, 2014-present.
Journal of Clinical Otolaryngology Head and Neck Surgery. 2015-present.

 

Research and Creative Activities:

Research Grants
(1). “ The prevention and treatment of antibiotic ototoxicity” supported by Shanghai High-Education Bureau (1981-1983).
(2). “ The experimental study of microcirculative barrier in inner ear” supported by China’ s Natural Science (1983-1985).
(3). “ Development of intercellular junction in human vestibular receptor” supported by Chinese Education Committee (1988-1990).
(4). “ A study on intercellular junction of the vestibular epithelium” supported by Shanghai High-Education Bureau (1989-1991).
(5). “ The binding site of aminoglycoside antibiotics in hair cells” supported by China’ s Natural Science (1990-1993).
(6). “ The microwave therapy for the deafness caused by deficiency of the inner ear microcirculation” supported by China’ s Natural Science (1991-1993).
(7). “ The experimental study on regeneration of the hair cells” supported by Chinese Health Department (1993-1995).
(8). “ Effects of inner hair cell loss on auditory function” supported by NIH, NIDCD, Richard J. Salvi, P.I.
(9). “ Selective inner hair cell loss: Effects on hearing” supported by NIH, NIDCD, Richard J. Salvi, P.I.
(10). “ Recovery of function and structure after acoustic trauma” supported by NIH, NIDCD, Richard J. Salvi, P. I.
(11). “Carboplatin ototoxicities” supported by China’ s Natural Science (2002-2004).
(12). “Compound Chinese traditional medicine compound protects hearing from aging” supported by Guiangxi science fund (2004-2007).
(13). “Effect of IHC loss on auditory function” supported by NIH/NIDCD (2004-2009). ($227.500).
(14). “Modulation of age related changes in the auditory system” Subcontract with University of South Florida (2003-2008). ($36, 548/year).
(15). “Genetics of age-related hearing loss” Subcontract with The Jackson Laboratory Boston (2007-2013). ($50,000/year).
(16). “Animal Models of Tinnitus, Brain Imaging & Therapy” supported by NIH (2007-2012). ($2,889,760).
(17)” Neural Aspects of Tinnitus” supported by NIH (2008-2013). ($1,678,098).
(18) “Study of NSCs with Ad/bcl-2 transplanted into sensorineural deafness rat cochlea demaged by ouabain” supported by China Natural Science (2010-2013). (¥350,000)
(19) “Tinnitus Susceptibility, Chronic Stress and Drug Therapy” supported by Office of Naval Research (2012-2014) ($187,890/yr)
(20) “Blast Wave Effects: Hearing, Memory, Therapy” supported by NIH (2012-2017) ($253,730/yr)
(21) “Subcontract on NIDCD grant awarded to Tomas Prolla: The Role of Mitochondria in Age-Related Hearing Loss” supported by NIDCD (2012-2017) ($100,137/yr)
(22) “Occupational Exposure to Manganese and Noise Potentiate Hearing Loss” supported by NIOSH (2012-2016) ($310,804/yr)
(23) “Lead-induced neurotoxicity and ototoxicity” supported by China Natural Science (81300819).

Publications: Comprehensive List
Please click here for a comprehensive list of Dr. Ding’s publications from 1981 to present.

Publications: 2012-Present
2012
Xuewen Wu, Dalian Ding, Haiyan Jiang, Xiaowei Xing, Suping Huang, Hong Liu, Zhedong Chen, Hong Sun. Transfection using hydroxyapatite nanoparticles in the inner ear via intact round window membrane in chinchilla. J Nanopar Res, 2012

Kelly L. Kane, Chantal M. Longo-Guess, Leona H. Gagnon, Dalian Ding, Richard J. Salvi, Kenneth R. Johnson. Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice. Hearing research, 2012; 283: 80-88.

Samson Jamesdaniel, Donald Coling, Sneha Hinduja, Dalian Ding, Jun Li, Linda Cassidy, Gail Seigel, Jun Qu, Richard Salvi. Cisplatin-induced ototoxicity is mediated by nitroxidative modification of cochlear proteins characterized by nitration of Lmo4. J Biol Chem, 2012; 287(22): 18674-18686.

Yong Fu, Dalian Ding, Haiyan Jiang, Richard Salvi. Ouabain-induced cochlear degeneration in rat. NeuroToxicity Research, 2012; 22 (2): 158-169.

Dalian Ding, Brian L. Allman, Richard Salvi. Review: Ototoxic characteristics of platinum antitumor drugs. Journal of Anatomical Record. Special Issue “The Anatomy and Biology of Hearing & Balance, Cochlear & Vestibular Implants”, Thomas van de Water Guest Editor. 2012; 295: 1851-1867.

Haibo Ye, Haibo Shi, Jian Wang, Dalian Ding, Dongzhen Yu, Zhengnong Chen, Chunyan Li, Weitian Zhang, Shankai Yin. Bilirunbin induces auditory neuropathy in neonatal guinea pigs via auditory nerve fiber damage. Journal of Neuroscience Research, 2012; 90(11): 2201-2213.

Dalian Ding, Haiyan Jiang, Yong Fu, Richard Salvi, Shionichi Someya, Masaru Tanokura. Ototoxic effects of carboplatin in organotypic cultures in chinchillas and rats. Journal of Otology, 2012; 7(2): 92-101.

2013
Dalian Ding, Jingchun He, Dongzhen Yu, Haiyan Jiang, Yongqi Li, Richard Salvi. New insights on cisplatin ototoxicity. Canadian Hearing Report, 2013; 8(1): 29-31.

Sarah Hayes, Dalian Ding, Richard Salvi, Brian L. Allman. Anatomy and physiology of the external, middle and inner ear. In: Celesia, G., (Ed.), Disorders of Peripheral and Central Auditory Processing, 2013; Vol. 10. Chapter 1: 3-23.

Minal Patel, Qunfeng, Cai, Dalian Ding, Richard Salvi, Z Hu, Bohua Hu. The miR-183/taok1 target pair is implicated in cochlear responses to acoustic trauma. PLosOne, 2013;

Lili Deng, Dalian Ding, Jiping Su, Snethilvelan Manohar, Richard Salvi. Salicylate selectively kills cochlear spiral ganglion neurons by paradoxically up-regulating superoxide. Neurotoxicity Research, 2013; 24(3): 307-319.

Richard Salvi, Dalian Ding, Wei Sun, Edward Lobarinas, Jian Wang, Animal model with auditory neuropathy-like characteristics. Italian audiology text book, 2013;

Jianxin Bao, Michelle Hungerford, Randi Luxmore, Dalian Ding, Ziyu Qiu, Debin Lei, Aizhen Yang, Ruqiang Liang, Kevin K. Ohlemiller. Prophylactic and therapeutic functions of drug combinations against noise-induced hearing loss. Hearing Research. 2013; 304: 33-40.

Dalian Ding, Haiyan Jiang, Yong Fu, Yongqi Li, Richard Salvi. Ototoxic model of oxaliplatin and protection from nicotinamide adenine dinucleotide. Journal of Otology. 2013. 8(1): 22-30.

Yong Fu, Dalian Ding, Lei Wei, Haiyan Jiang, Richard Salvi. Ouabain-induced apoptosis in cochlear hair cells and spiral ganglion neurons in vitro. BioMed Research International. 2013;

Lu Wang, Dalian Ding, Hong Sun, Richard Salvi. Introspection of oxidant / antioxidant imbalance in the inner ear. Journal of Clinic Otorhinolaryngology Head Neck Surgery. 2013; 27(17): 965-974.

Edward Lobarinas, Richard Salvi, Dalian Ding. Insensitivity of the audiogram to carboplatin induced inner hair cell loss in chinchillas. Hearing Research. 2013; 302: 113-120.

Suzanne Kraus, Dalian Ding, Haiyan Jiang, Mohammad Habiby Kermany, Sucharita Mitra, Richard Salvi. Up-regulation of GAP-43 in the chinchilla ventral cochlear nucleus after carboplatin-induced hearing loss: Role of inner hair cell loss and outer hair cell loss. Hearing Research. 2013; 302: 74-82.

Guangdi Chen, Daniel Stolzberg, Edward Lobarinas, Wei Sun, Dalian Ding, Richard Salvi. Salicylate-induced cochlear impairments, cortical hyperactivity and re-tuning, and tinnitus. Hearing Research. 2013; 295: 100-113.

Dalian Ding, Weidong Qi, Dongzhen Yu, Haiyan Jiang, Chul Han, Mi-Jung Kim, Kana Katsuno, Yun Hua Hsieh, Takuya Miyakawa, Richard Salvi, Masaru Tanokuram Shinichi Someya. Addition of exogenous NAD+ prevents mefloquine-induced neuroaxonal and hair cell degeneration through reduction of caspase-3-mediated apoptosis in cochlear organotypic cultures. PLOS ONE. 2013; 8: e79817.

Jintao Yu, Dalian Ding, Hong Sun, Shankai Yin, Richard Salvi. Neurotoxicity and ototoxicity of trimethyltin. Chinese Journal of Otology. 2013; 11(4): 603-608.

2014
Dalian Ding, Richard Salvi, Jerome A. Roth. Cellular localization and developmental changes of the different isoforms of divalent metal transporter 1 (DMT1) in the inner ear of rats. BioMetals. 2014;27(1): 125-134.

Weidong Qi, Dalian Ding, Huaxin Zhu, Daru Lu, Yingming Wang, Jianfeng Ding, Wenhong Yan, Minghui Jia, Yongwei Guo. Efficient siRNA transfection to the inner ear through the intact round window by a novel proteidic delivery technology in the chinchilla. Gene Therapy, 2014; 21(1):10-8.

Lu Wang, Dalian Ding, Richard Salvi, Jerome A. Roth. Nicotinamide adenine dinucleotide prevents neuroaxonal degeneration induced by manganese in cochlear organotypic cultures. NeutoToxicology 40: 65-74.

Jintao Yu, Dalian Ding, Hong Sun, Richard Salvi. Recording of cochlear bioelectricities from facial nerve canal in rats. Chinese Journal of Otology. 2014; 12 (1): 34-41.

Hong Liu, Dalian Ding, Hong Sun, Haiyan Jiang, Xuewen Wu, Jerome A. Roth, Richard Salvi. Cadmium-induced ototoxicity in rat cochlear organotypic cultures. Neurotoxicity Research. 2014;26(2): 179-189.

Dalian Ding, Richard Salvi, Jerome A. Roth. Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats. Biometals. 2014; 27(4): 731-744.

Yang Dong, Dalian Ding, Haiyan Jiang, Jianrong Shi, Richard Salvi, Jerome A. Roth. Ototoxicity of paclitaxel in rat cochlear organotypic cultures. Toxicology and Applied Pharmacology. 2014; 280(3): 526-533.

Richard Salvi, Dalian Ding, Wei Sun, Edward Lobarinas, Jian Wang. Animal model with auditory neuropathy-like characteristics. In: Ambrosetti, U., di Berardino, F., del Bo, L., (Eds.), The Hearing aid technician’s Handbook. Edizioni Minerva Medica, Torino, Italy. 2014; pp. 247-263.

Stacia R. Wegst-Uhrich, Ellzabath J. Mullin, Dalian Ding, Senthilvelan Manohar, Richard Salvi, Diana S. Aga, Jerome A. Roth. Endogenous concentration of biologically relavant metals in rat brain and cochlea determined by inductively coupled plasma mass spectrometry. Biometals, 2014; DOI 10.1007/s10534-014-9814-8.

Jintao Yu, Dalian Ding, Fenjun Wang, Haiyan Jiang, Hong Sun, Richard Salvi. Pattern of hair cell loss and delayed peripheral neuron degeneration in inner ear by a high-dose intratympanic gentamicin. Journal of Otology. 2014; 9: 126-135.

2015
Andrew J. Newman, Sarah H. Hayes, Abhiram S. Rao, Brain L. Allman, Senthilvelan Manohar, Dalian Ding, Daniel Stolzberg, Edward Lobarinas, Joseph C. Mollendorf, Richar Salvi. Low-cost blast wave generator for studies of hearing loss and brain injury: Blast wave effects in closed spaces. Journal of Neuroscience Methods. 2015; 242: 82-92.

Dalian Ding, Jintao Yu, Peng Li, Kelei Gao, Haiyan Jiang, Wenjuan Zhang, Hong Sun, Shankai Yin, Richard Salvi. Standardization of temporal bone sections in experimental animals. Chinese Journal of Otology. 2015; 13(1):1-6.

Peng Li, Kelei Gao, Dalian Ding, Richard Salvi. Charateristic anatomical structures of rat temporal bone. Chinese Journal of Otology. 2015; 13(1):7-12.

Peng Li, Dalian Ding, Kelei Gao, Richard Salvi. Standard surgical approaches to ear surgery in rats. Chinese Journal of Otology. 2015; 13(1):13-17.

Kelei Gao, Peng Li, Haiyan Jiang, Dalian Ding, Hong Sun, Richard Salvi. Rat inner ear structures and micro-dissection techniques. Chinese Journal of Otology. 2015; 13(1):18-24.

Kelei Gao, Dalian Ding, Peng Li, Hong Sun, Richard Salvi. Damaging effects of aminoglycoside antibiotics on cochlear spiral ganglion neurons. Chinese Journal of Otology. 2015; 13(1):37-42.

Kelei Gao, Dalian Ding, Peng Li, Hong Sun, Richard Salvi. Thiamine deficiency and hearing loss. Chinese Journal of Otology. 2015; 13(1):43-48.

Peng Li, Dalian Ding, Xiangli Zeng, Richard Salvi. Experimental animal models with features of auditory neuropathy. Chinese Journal of Otology. 2015; 13(1):49-56.

Peng Li, Dalian Ding, Xiangli Zeng, Richard Salvi, Jerome A. Roth. Neurotoxicity and ototoxicity of cobalt. Chinese Journal of Otology. 2015; 13(1):57-63.

Jintao Yu, Dalian Ding, Peng Li, Kelei Gao, Hiayan Jiang, Hong Sun, Richard Salvi. Technical details of sample preparation for inner ear organotypic cultures. Chinese Journal of Otology. 2015; 13(1):64-70.

Liang Zong, Jing Guan, Megan Ealy, Qiujing Zhang,Dayong Wang, Hongyang Wang, Yali Zhao, Zhirong Shen, Colleen A Campbell, Fengchao Wang, Ju Yang, Wei Sun, Lan Lan, Dalian Ding, Linyi Xie, Yue Qi, Xin Lou, Xusheng Huang, Qiang Shi, Suhua Chang, Wenping Xiong, Zifang Yin, Ning Yu, Hui Zhao, Jun Wang, Jing Wang, Richard J Salvi, Christine Petit, Richard J H Smith, Qiuju Wang. Mutations in apoptosis-inducing factor cause X-linked recessive auditory neuropathy spectrum disorder. J Med Genet 2015;0:1–9. doi:10.1136/jmedgenet-2014-102961

Jintao Yu, Dalian Ding, Hong Sun, Richard Salvi, Jerome A. Roth. Neurotoxicity of trimethyltin in rat cochlear organotypic cultures. Neurotoxicity Research. 2015; 28: 43-54.

Dalian Ding, Peng Li, Kelei Gao, Haiyan Jiang, Hong Sun, Chengfang Chen, Richard Salvi. Identification of cochlear cell death. Chinese Journal of Otorhinolaryngology-Skull Base Surgery. 2015; 21(3): 178-183.

Peng Li, Dalian Ding, Richard Salvi, Jerome A. Roth. Cobalt-induced ototoxicity in rat postnatal cochlear organotypic cultures. Neurotoxicity Research. 2015;28: 209-221.

Joan S. Baizer, Keit Men Wong, Richard J. Salvi, Sarah H. Hayes, Senthilvelan Manohar, Dalian Ding, Robert Dingman. Effects of acoustic trauma on the auditory system of the rat: the role of microglia. Neuroscience. 2015;303:299-311.

Dalian Ding, Jintao Yu, Peng Li, Kelei Gao, Haiyan Jiang, Wenjuan Zhang, Hong Sun, Shangkai Yin, Richard Salvi. Standardization of experimental animals temporal bone sections. Journal of Otology. 2015; 10(2): 66-71

Peng Li, Dalian Ding, Kelei Gao, Richard Salvi. Standardized surgical approaches to ear surgery in rats. Journal of Otology. 2015; 10(2): 72-77.

Elizabeth J. Mullin, Stacia R. Wegst-Uhrich, Dalian Ding, Senthilvelan Manohar, Vijaya Prekash Krishnan Muthaiah, Richard Salvi, Diana S. Aga, Jerome A. Roth. Effect of manganese treatment on the accumulation on biologically relevant metals in rat cochlea and brain by inductively coupled plasma mass spectrometry. BioMetals. 2015; DOI 10.1007/s10534-015-9885-1

Jintao Yu, Dalian Ding, Hong Sun, Richard Salvi. Ototoxic effects of heavy metals. Chinese Journal of Otorhinolaryngology in Integrative Medicine. 2015; 23(5): Edward Lobarinas, Richard Salvi, Dalian Ding. Selective inner hair cell dysfunction in chinchillas impairs hearing-in-noise in the absence of outer hair cell loss. Journal of the Association for Research in Otolaryngology 2015.

2016
Senthilvelan Manohar, Samson Jamesdaniel, Dalian Ding, Richard Salvi, Gail M. Seigel, Jerome A. Roth. Quantitative PCR analysis and protein distribution of drug transporter genes in the rat cochlea. Hearing Research 2016; 332: 46-54.

Kelly Radziwon, Sarah H. Hayes, Adam M. Sheppard, Dalian Ding, Richard Salvi. Drug-induced tinnitus. Tinnitus. Clinical and Research Perspectives. David M. Baguley, Marc Fagelson. Plural Publishing Inc. San Diego 2016. 89-109.

Christopher Spankovich, Edward Lobarinas, Dalian Ding, Richard Salvi, Colleen G. Le Prell. Assessment of thermal treatment via irrigation of external ear to reduce cisplatin-induced hearing loss. Hearing Research 2016; 332: 55-60.

Kun Yang, Dalian Ding, Yong Fu, Yongqi Li, Haiyan Jiang, Richard Salvi. Systemic detection of cisplatin-induced apoptosis by fluorescently-labeled poly-caspase inhibitor (FLIVO). Chinese Journal of Otology. 2016; 14(1): 112-118.

 

Teaching:

Visiting Professor, Otologic laboratory in Jiamusi Medical University, 1992- 1994.
Visiting Professor, Shanghai Otologic laboratories in Shanghai 6th Hospital, 1994-1995.
Research Professor, Department of Otolaryngology-Head and Neck Surgery in Shanghai Renji Hospital, 2001-2007.

Academic Committee Member on the Board of Institute of Otorhinolaryngology,
Tongji Medical College, Huazhong University of Science and Technology, 2001-present.

Visiting Professor, Shanghai Yue Yang Hospital, 2002-2006.

Honorary Chairman and Visiting Professor, Lin Hai Otorhinolaryngology Institute, 2002-present.

Vice-chairman and Visiting Professor. Shanghai Otolaryngology Institute( September 2006-present).