Gail M. Seigel, Ph.D.

Research Associate Professor
Office: 42 Cary Hall
Phone: (585) 281-3059
Email: gseigel@frontiernet.net

Current Work:

Reversible differentiation of cancer stem cells in retinoblastoma

Tumor initiating cells in retinoblastoma

The Physical Basis of the Progression of Metastatic Cancer

 

Education / Training:

Ph.D. Microbiology/Immunology Albany Medical College 1990
B.S. Microbiology 1983 Rutgers University

 

Employment / Professional Experience:

Research Associate Professor
Department of Communicative Disorders and Sciences
University at Buffalo, the State University of New York
Buffalo, NY 2007 – present

Assisant Professor/Clinical Assistant Professor
Ophtalmology
Joint Appointment with Physiology & Biophysics
University at Buffalo, the State University of New York
Buffalo, NY 2007 – 2009

Research Assistant Professor
Department of Neurobiology/Anatomy
University of Rochester
Rochester, NY 1996-1999

Research Assistant Professor
Ophthalmology Department
University of Rochester
Rochester, NY 2000-2001

Scientist
Department of Neurobiology/Anatomy
University of Rochester
Rochester, NY 1993-1996

Postdoctoral Fellow
Department of Neurobiology/Anatomy
University of Rochester
Rochester, NY 1989-1993

Graduate Research Assistant
Department of Microbiology/Immunol
Albany Medical College
Albany, NY 1983-1989

Independent Study
Department of Microbiology/Microchemistry
Rutgers, the State University of New Jersey
New Brunswick, NJ 1983

Laboratory Assistant
Department of Microbiology
University of Rochester
Rochester, NY 1982

 

Professional Honors/ Advisory and Editorial Boards:

Fellow of the Association for Research in Vision and Ophthalmology 2009
Fight for Sight 2006 Award of Merit
Research to Prevent Blindness: Cybil Harrington Research Scholar Award
National Merit Letter of Commendation
New York State Regents Scholarship
American Society for Microbiology Student Research Award
Who’s Who in Science & Engineering
Career Development Award, United University Professionals

 

Research and Creative Activities:

Seigel, GM. 2010. Differentiation potential of human retinoblastoma cells. Curr. Pharm. Biotechnology, in press.

Silva A, Yi, H, Seigel, GM and AS Hackam. 2010. Lithium chloride regulates the proliferation of stem cells in retinoblastoma cell lines: a potential role for the canonical Wnt signaling pathway, Mol. Vision 2010; 16:36-45.

Kelly, J, Rowell, G., Weiss, A., Seigel, GM. 2009. Autofluorescence and Infrared Retinal Imaging in Patients and Obligate Carriers with Neuronal Ceroid Lipofuscinosis, Ophthalmic Genetics 30(4):190-8.

Hayes, SH and Seigel, GM. 2009. Immunoreactivity of ICAM-1 in human tumors, metastases and normal tissues. Int. J. Clin. Exp. Pathol. 2 (6): 553-560.

Patil, AJ, Gramajo, AL, Sharma, A .Chwa, M., Seigel, GM, Kepperman, BD, Kenney, MC. 2009. Effects of Benzo(e)Pyrene on the Retinal Neurosensory Cells and Human Microvascular Endothelial Cells In Vitro Current Eye Research 34, (8), 672 – 682.

Patil AJ, Gramajo AL, Sharma A, Seigel GM, Kuppermann BD, Kenney, MC. 2009. Differential toxicity of nicotine on retinal and vascular cells. Toxicology, 69-76.

Magupalli V., Schwarz K., Alpadi K, Natarajan S., Seigel GM, and F. Schmitz 2008. Multiple RIBEYE-RIBEYE interactions create a dynamic scaffold for the formation of synaptic ribbons, J. Neurosci., 28(32):7954-67.

Brust AK, Ulbrich HK, Seigel GM, Pfeiffer N, Grus FH. 2008. Effects of Cyclooxygenase Inhibitors on Apoptotic Neuroretinal Cells. Biomark Insights. Jul 8;3:387-402.

Alpadi, K., Magupalli, V., Käppel S., Köblitz L., Schwarz K., Seigel GM, Sung C. and F. Schmitz 2008. Ribeye recruits Munc119, a mammalian ortholog of the c. elegans protein unc119, to synaptic ribbons of photoreceptor synapses, J. Biol. Chem in press.

Ekici M., Schmitz F., Seigel GM and G. Thiel 2008. The synapsin I and synaptophysin genes are embedded into active chromatin in retinal precursor cells and gene transcription is regulated by histone acetylation and the transcription factor REST. Neurochemistry Int., in press.

Seigel, GM, Hackam, A, Ganguly, A Gonzalez-Fernandez, F. 2007. Embryonic and neuronal stem cell markers in retinoblastoma, Molecular Vision, 13:823-832.

Neekhra A, Luthra S, Chwa M, Seigel G, Gramajo AL, Kuppermann BD, Kenney MC. 2007. Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells. Invest Ophthalmol Vis Sci Mar;48(3):1362-7.

Nagai-Kusuhara A, Nakamura M, Mukuno H, Kanamori A, Negi A, Seigel GM.

2006. cAMP-responsive element binding protein mediates a cGMP/protein kinase G-dependent anti-apoptotic signal induced by nitric oxide in retinal neuro-glial progenitor cells. Exp Eye Res. Oct 31; [Epub ahead of print]

Seigel, GM, Lupein, SB, Campbell, LM, Ishii, DN. 2006. Systemic IGF-1 treatment inhibits cell death in diabetic rat retina. J. Diab. & Complications May-Jun;20(3):196-204.

Ding, D. Seigel, GM, Salvi, R. 2006. Migration of R28 retinal precursor cells into cochlear and vestibular organs. J. Otology 1: 51-56.

Nakanishi Y, Nakamura M, Mukuno H, Kanamori A, Seigel GM, Negi A. 2006. Latanoprost rescues retinal neuro-glial cells from apoptosis by inhibiting caspase-3, which is mediated by p44/p42 mitogen-activated protein kinase. Exp Eye Res. Jul 11; [Epub ahead of print].

Narayanan R, Mungcal JK, Kenney MC, Seigel GM, Kuppermann BD. 2006. Toxicity of triamcinolone acetonide on retinal neurosensory and pigment epithelial cells. Invest Ophthalmol Vis Sci. 47(2):722-8.

Luthra S, Narayanan R, Marques LE, Chwa M, Kim DW, Dong J, Seigel GM, Neekhra A, Gramajo AL, Brown DJ, Kenney MC, Kuppermann BD. 2006. Evaluation of the in vitro effects of Bevacizumab (Avastin) on retinal pigment epithelial, neurosensory retinal, and microvascular endothelial cells. Retina. 26(5):512-518.

Seigel, G.M., Campbell, LM, Narayan, M., and Gonzalez-Fernandez, F. 2005. Cancer stem cell characteristics in retinoblastoma. Molecular Vision 11: 729-737.

Narayanan, R., Kenney, MC, Kamjoo, S, Trinh, THT, Seigel, GM, Resende, GP, Kuppermann, BD. 2005. Trypan Blue: Effect on retinal pigment epithelial and neurosensory retinal cells. Inv. Ophth. & Vis Sci. 46:304-309.

Narayanan, R., Kenney, MC, Kamjoo, S, Trinh, THT, Seigel, GM, Resende, GP, Kuppermann, BD. 2005. Toxicity of indocyanine green (ICG) in combination with light on human retinal pigment epithelial cells and rat neurosensory retinal cells, Current Eye Research, in press.

Seigel, GM and L M Campbell. 2004. High throughput microtiter assay for Hoechst 33342 dye uptake. Cytotechnology, 45: 155-160.

 

Teaching:

Developmental Genomics class

Developmental Neuroscience class

Cell Growth, Differentiation and Transformation class

Mentor of undergraduate research students