University at Buffalo - The State University of New York
Skip to Content

Guang-Di Chen

Research Professor
Office: 137E Cary Hall
Office Phone: 716.829.2001 x21
Email: gchen7@buffalo.edu

Education

02/1982
Bachelor Degree of Science (BS, Biology)
Nanjing Normal University, Nanjing, Jiangsu province, China

01/1985
Master Degree of Science (MS, Auditory Physiology)
Shanghai Institute of Physiology, Chinese Academy of Science, Shanghai, China

09/1989
Doctor Degree of Philosophy (Ph.D., Auditory Neuroscience)
Shanghai Institute of Physiology, Chinese Academy of Science, Shanghai, China

Employment / Professional Experience:

06/2013 ------ present
Research Professor, Research Scientist (To study the mechanisms underlying hearing loss/tinnitus and the hearing protection)
Center for Hearing & Deafness, SUNY at Buffalo, Buffalo, NY

07/2005 ------ 06/2013
Associate Research Professor, Research Scientist (To study the mechanisms underlying hearing loss/tinnitus and the hearing protection)
Center for Hearing & Deafness, SUNY at Buffalo, Buffalo, NY

09/2000 ------ 07/2005
Assistant Research Professor (To study the mechanisms underlying hearing loss and the hearing protection)
College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK
04/1998 ------ 09/2000
Research Associate (To study the mechanisms underlying hearing loss and the hearing protection)
College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK

01/1993 ------ 04/1998
Research Associate (To study neural coding of speech sounds)
Boys Town National Research Hospital, Omaha, NE &
Dept. of Speech and Hearing Science, Arizona State University, Tempe, AZ

01/1990 ------ 12/1992
Postdoctoral fellow (To study the mechanisms underlying tinnitus)
Dept. of Surgery, Yale University, School of Medicine, New Haven, Connecticut &
Dept. of Surgery, University of Maryland, School of Medicine, Baltimore, MD

Research Grants
Title: Hyperacusis and central gain
PI: Richard Salvi; co-I: Guang-Di Chen
Agency: NIHR01: 1R01DC014693
Period: 12/2015 ------ 12/2020

Title: Neural basis of hyperacusis
PI: Richard Salvi; co-I: Guang-Di Chen
Agency: NIHR01: 1R01DC014452
Period: 04/2016 ------ 04/2021

Title: Occupational exposure to manganese and noise potentiate hearing loss
PI: Jerome Allan Roth and Richard Salvi (Dalian Ding and Guang-Di Chen: co-I)
Agency: National Institute for Occupational Safety and Health (NIOSH): R01OH010235
Period: 07/2012 ------ 06/2017

Title: Influences of hypoxia on noise induced hearing loss.
Goal: To study the effects of hypoxia on noise-induced hearing loss.
PI: Guang-Di Chen
Agency: NIHR03
Period: 08/2001 ------ 07/2006

Title: Effect of intense noise on outer hair cell membrane fluidity.
Goal: To study the effects of intense noise on outer hair cell membrane fluidity after noise exposure.
PI: Guang-Di Chen
Agency: Yamanouchi USA Foundation
Period: 05/2003 ------ 04/2004

Title: Drug development for methamphetamine.
Goal: To validate sigma receptors as a drug development target for the treatment of methamphetamine abuse.
PI: Guang-Di Chen (Y3), Rae Matsumoto (Y1-2)
Agency: Oklahoma Center for the Advancement of Science and Technology.
Period: 07/2002 ------ 06/2005

Publications

78. Jiang, C., Chen, G.D., Sheppard, A., Salvi, R. 2016. Plastic changes in the brain along auditory pathway during salicylate-induced tinnitus and hyperacusis. Hear. Res. (under review)

77. Ding, D., Jiang, H.Y., Chen, G.D., Longo-Guess, C., Krishnan Muthaiah, V.P., Tian, C., Sheppard, A., Salvi, R., Johnson, K. 2016. N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in -glutamyl transferase 1 deficient mice. Aging (in press)

76. Chen, G.D., Sheppard, A., Salvi, R. 2016. Noise trauma induced plastic changes in brain regions outside the classical auditory pathway. Neurosci. Neurosci. 315, 228-245.

75. Sheppard, A., Chen, G.D., Salvi, R. 2015. Potassium ion channel openers, maxipost and retigabine, protect against peripheral salicylate ototoxicity. Hear. Res. 327, 1-8.

74. Chen, Y.C., Li, X.W., Liu, L.J., Wang, J., Lu, C.Q., Yang, M., Jiao, Y., Zang, F.C., Radziwon, K., Chen, G.D., Sun, W., Krishnan Muthaiah, V.P., Salvi, R., Teng, G.J. 2015. Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network. Elife. 2015 May 12; 4. Dio: 10.7554/elife.06576

73. Abiraman, K., Pol, S., O'Bara, M., Chen, G.D., Khaku, Z., Wang, J., Thorn, D., Vedia, B., Ekwegbalu, E., Li, J.X., Salvi, R., Sim, F. 2015. Anti-Muscarinic adjunct therapy accelerates functional human oligodendrocyte repair. J. Neurosci. 35(8), 3676-3688.

72. Chen, G.D., Decker, B., Krishnan Muthaiah, V.P., Sheppard, A., and Salvi, R. 2014. Prolonged noise exposure-induced auditory threshold shifts in rats. Hear. Res. 317, 1-8.

71. Sheppard, A., Hayes, S., Chen, G.D., Ralli, M., Salvi, R., 2014. Review of Salicylate-Induced Hearing Loss, Neurotoxicity, Tinnitus, and Neuropathophysiology. Acta Otorhinolaryngol. Ital. 34(2), 79-93.

70. Chen, G.D., Radziwon, K.E., Kashanian, N., Manohar, S., Salvi, R., 2014. Salicylate-Induced Auditory Perceptual Disorders and Plastic Changes in Non-Classical Auditory Centers in Rats. Neural Plasticity, Volume 2014 (2014), Article ID 658741, 18 pages

69. Zhu, Y., Liang, C., Chen, J., Zong, L., Chen, G.D., Zhao, H. B., 2013. Active cochlear amplification is dependent on supporting cell gap junctions. Nature Communications. 4:1786. DOI 10.1038/Ncomms2806.

68. Chen, G.D., 2013. The relationship between hearing loss and auditory hair cell loss in rats. Canadian Hearing Report. 8(1): 39-40.

67. Bielefeld, E.C., Tanaka, C., Chen, G.D., Coling, D., Li, M.N., Henderson, D., Fetoni, A.R., 2013. A Src-PTK inhibitor to reduce cisplatin ototoxicity while preserving its anti-tumor effect. Anti-Cancer Drugs. 24(1), 43-51.

66. Chen, G.D., Stolzberg, D., Lobarinas, E., Sun, W., Ding, D., Salvi, R., 2013. Review: Salicylate-induced cochlear impairments, cortical hyperactivity and re-tuning, and tinnitus. Hear. Res. 295: 100-113.

65. Chen, G.D., Manohar, S., Salvi, R., 2012. Amygdala hyperactivity and tonotopic shift after salicylate exposure. Brain Res. 1485: 63-76.

64. Tanaka, C., Coling, D., Manohar, S., Chen, G.D., Hu, B.H., Salvi, R., Henderson, D., 2012. Expression pattern of oxidative stress and antioxidant defense-related genes in the aging Fischer 344/NHsd rat cochlea. Neurobiology of Aging. 33: 1842.e1-1842.e14.

63. Yang, W., Hu, B., Chen, G.D., Bielefeld, E.C., Henderson, D., 2011. L-NAC protect hair cells in the rat cochlea from injury of exposure to styrene. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 25(4):176-179.

62. Chen, G.D., Henderson, D., 2011. Ototoxicity of styrene. Journal of Otology, 6(2): 1-9.

61. Chen, G.D., Lobarinas, E., Ding, D., Salvi, R., 2011. Hearing loss: what's in the pipeline. Drugs of the Future. 36 (3): 209-227. Doi: 10.1358/dof.2011.036.03.1584111

60. Stolzberg, D., Chen, G.D., Allman, B., Salvi, R., 2011. Salicylate-induced peripheral auditory changes and tonotopic reorganization of auditory cortex. Neurosci. 180, 157-164.

59. Salvi, R., Lobarinas, E., Chen, G.D., Stolzberg, D., Ding, D., 2011. Animal Models of Hearing Loss and Tinnitus. CRC Handbook, Chapter 18, 419-453.

58. Allman, B.L., Sun, W., Kraus, K.S., Ding, D., Chen, G.D., Stolzberg, D., Lobarinas, E., Salvi, R. 2010. Central auditory system neuroplasticity and hippocampal neurogenesis following ccohlear insults. In: Salami, A., (Ed.), Neuroplasticity in the auditory brainstem: from physiology to the drug therapy. Nova Science Publishers, Hauppauge, NY.

57. Chen, G.D., Habiby Kermany, M., D’Elia, A., Ralli, M., Tanaka, C., Bielefeld, E.C., Ding, D., Henderson, D., Salvi, R., 2010. Too much of a good thing: Long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity. Hear. Res. 265, 63-69.

56. Bielefeld, E.C., Tanaka, C., Chen, G.D., Henderson, D., 2010. Age-related hearing loss: Is it a preventable condition? Hear. Res. 264, 98-107.

55. Tanaka, C., Bielefeld, E.C., Chen, G.D., Li, M.N., Henderson, D., 2009. Ameliorative Effects of an Augmented Acoustic Environment on Age-Related Hearing Loss in Middle-Aged Fischer 344/NHsd. Laryngoscope 119, 1374-1379.

54. Kong, L., Chen, G.D., Zhou, X.H., McGinnis, J.F., Li, F., Cao, W., 2009. Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane. Neurochem. Int. 54, 172-179.

53. Chen, G.D., Henderson, D., 2009. Cochlear injuries induced by the combined exposure to noise and styrene. Hear. Res. 254, 25-33.

52. Yang, W.P., Hu, B.H., Chen, G.D., Bielefeld, E.C., Henderson, D., 2009. Protective effect of N-acety-L-cysteine (L-NAC) against styrene-induced cochlear injuries. Acta Oto-Laryngologica. 129, 1036-1043.

51. Tanaka, C., Chen, G.D., Hu, B.H., Chi, L.H., Li, M.N., Zheng, G.L., Bielefeld, E.C., Jamesdaniel, S., Coling, D., Henderson, D., 2009. The Effects of Acoustic Environment after Traumatic Noise Exposure on Hearing and Outer Hair Cells. Hear. Res. 250, 10-18.

50. Chen, G.D., Li, M.N., Tanaka, C., Bielefeld, E., Hu, B.H., Habiby Kermany, M., Salvi, R., Henderson, D., 2009. Aging outer hair cells (OHCs) in the Fischer 344 rat cochlea: Function and morphology. Hear Res. 248, 39-47.

49. Chen, G.D., 2008. Chapter 37: Noise. In: Information Resources in Toxicology, 4th edition. Eds by Philip Wexler, Steve Gilbert, Bert Hakkinen, Asish Mohapatra, Fred Stoss. Academic Press. Amsterdam, Boston, Heideiberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo. pp 323-327.

48. Hu, B.H., Yang, W.P., Bielefeld, E.C., Li, M.N., Chen, G.D., Henderson, D., 2008. Apoptotic sensory cell death in the cochleae of aging Fischer 344 rats. Hear. Res. 245, 48-57.

47. Chen, G.D., Tanaka, C., Henderson, D., 2008. Relationship between outer hair cell loss and hearing loss in rats exposed to styrene. Hear. Res. 243, 28-34.

46. Bielefeld, E.C., Coling, D., Chen, G.D., Henderson, D., 2008. Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat. J. Negat. Results Biomed. 2008 Jul 11;7:4.

45. Bielefeld, E.C., Coling, D., Chen, G.D., Li, M.N., Tanaka, C., Hu, B.H., Henderson, D., 2008. Age-related hearing loss in the Fischer 344/NHsd rat substrain. Hear. Res. 241, 26-33.

44. Chen, G.D., Chi, L.H., Kostyniak, P.J., Henderson, D., 2007. Styrene induced alterations in biomarkers of exposure and effects in the cochlea: Mechanisms of hearing loss. Toxicol. Sci. 98(1), 167-177.

43. Chen, G.D., Zhao, H.B., 2007. Effects of intense noise exposure on the outer hair cell plasma membrane fluidity. Hear. Res. 226, 14-21.

42. Chen, G.D., 2006. Prestin gene expression in the rat cochlea following intense noise exposure. Hear. Res. 222, 54-61.

41. Liu, Y., Yu, Y., Shaikh, J., Pouw, B, Daniels, A., Chen, G.D. and Matsumoto, R. R., 2005. Sigma receptors and drug abuse. In R. R. Matsumoto, W. D. Bowen, and T.-P. Su (Eds.), Sigma Receptors: Chemistry, Cell Biology, and Clinical Implications, Springer-Verlag.

40. Liu, Y., Chen, G.D., Lerner, M.R., Brackett, D.J., Matsumoto, R.R., 2005. Cocaine up-regulates Fra-2 and  receptor gene and protein expression in brain regions involved in addiction and reward. The Journal of Pharmacology and Experimental Therapeutics. 314, 770-779.

39. Chen, G.D., Liu, Y., 2005. Mechanisms of noise-induced hearing loss potentiation by hypoxia. Hear. Res. 200, 1-9.

38. Chen, G.D., Fechter, L.D., 2003. The relationship between noise-induced hearing loss and hair cell loss in rats. Hear. Res. 177(1-2), 81-90.

37. Chen, G.D., 2002. Effect of hypoxia on noise-induced auditory impairment. Hear. Res. 172(1-2), 186-195.

36. Sinex, D.G., Henderson, J., Li, H.Z., Chen, G.D., 2002. Responses of chinchilla inferior colliculus neurons to amplitude-modulated tones with different envelopes. JARO. 3(4), 390-402.

35. Fechter, L.D., Chen, G.D., Johnson, D.L., 2002. Potentiation of noise induced hearing loss by low concentrations of hydrogen cyanide in rats. Toxicol. Sci. 66, 131-138.

34. Fechter, L.D., Chen, G.D., Rao, D., 2002. Chemical asphyxiants and noise. Noise and Health. 4(14), 49-62.

33. Fechter, L.D., Chen, G.D., Rao, D., 2001. Noise and occupational exposures. In: Noise Induced Hearing Loss: Basic Mechanisms, Prevention and Control. Eds by Henderson, D., Prasher, D., Kopke, R., Salvi, R., Hamernik, R. Noise Research Network Publications, London.

32. Tawackoli, W., Chen, G.D. and Fechter, L.D., 2001. Disruption of cochlear potentials by chemical asphyxiants Cyanide and carbon monoxide. Neurotoxicol. and Teratol. 23, 157-165.

31. Chen, G.D., Kong, J., Reinhard, K. and Fechter, L.D., 2001. NMDA-receptor blocker protects against permanent NIHL but not its potentiation by CO. Hear. Res. 154, 108-115.

30. Fechter, L.D., Chen, G.D. and Rao, D., 2000. Characterizing conditions that favor potentiation of noise induced hearing loss by chemical asphyxiants. Noise and Health. 3(9), 11-21.

29. Fechter, L.D., Chen, G.D. and Rao, D., Larabee, J., 2000. Predicting exposure conditions that facilitate the potentiation of noise-induced hearing loss by carbon monoxide. Toxicol. Sci. 58, 315-323.

28. McWilliams, M.L., Chen, G.D. and Fechter, L.D., 2000. Low level toluene disrupts auditory function in guinea pigs. Toxicol. Appl. Pharmaco. 167, 18-29.

27. McWilliams, M.L., Chen, G.D. and Fechter, L.D., 2000. Characterization of the ototoxicity of DFMO and its enantiomers. Toxicol. Sci. 56, 124-132.

26. Fechter, L.D., Chen, G.D. and Prasher, D., 2000. Assessment of ototoxicity. The Ear. 3, 73-82.

25. Chen, G.D., McWilliams, M. and Fechter, L.D., 2000. Succinate dehydrogenase (SDH) activity in hair cells: A correlate for permanent threshold elevations. Hear. Res. 145, 91-100.

24. Sinex, D.G. and Chen, G.D., 2000. Neural responses to the onset of voicing are unrelated to other measures of temporal sensitivity. J.Acoust. Soc. AM. 107, 486-495.

23. Chen, G.D. and Sinex, D.G., 1999. Effects of interaural time differences on the responses of chinchilla inferior colliculus neurons to consonant-vowel syllables. Hear. Res 138, 29-44.

22. Chen, G.D., McWilliams, M.L. and Fechter, L.D., 1999. Intermittent noise induced hearing loss and the influence of carbon monoxide. Hear. Res. 138, 181-191.

21. Chen, G.D. and Fechter, L.D., 1999. Potentiation of octave-band noise induced auditory impairment by carbon monoxide. Hear. Res. 132, 149-159.

20. Nuding, S.C., Chen, G.D. and Sinex, D.G., 1999. Monaural response properties of single neurons in the chinchilla inferior colliculus. Hear. Res. 131, 89-106.

19. Chen, G.D., 1998. Effects of stimulus duration on responses of neurons in the chinchilla inferior colliculus to pure tones. Hear. Res. 122, 142-150.

18. Chen, G.D., Nuding, S.C., Narayan, S.S. and Sinex, D.G., 1996. Responses of single neurons in the chinchilla inferior colliculus to consonant-vowel syllables differing in voice onset time. Auditory Neuroscience. 3, 179-198.

17. Jastreboff, P.J., Brennan, J.F., Jastreboff, M.M., Hu, S.M., Zhou, S.T., Chen, G.D., Gryczynska, U. and Kwapisz, U., 1995. Recent findings from an animal model of tinnitus. Proceedings of the 5th International Tinnitus Seminar, Portland, Oregon, eds. G. Reich and J. Vernon, American Tinnitus Association, pp. 114-126.

16. Chen, G.D., and Jastreboff, P.J., 1995. Salicylate-induced abnormal activity in the inferior colliculus of rats. Hear. Res. 82, 158-178.

15. Narayan, S.S. and Chen, G.D., 1994. Effect of complex-sound phase in the chinchilla auditory nerve. J. Acoust. Soc. Am. 95, 2app8. p. 2841.

14. Chen, G.D., Chen, L.Y. and Guo, Y.X., 1990. Responses of inferior colliculus neurons to AM and FM tones in guinea pigs. Chin. J. Physiol. Sci. 6, 248-256.

13. Chen, G.D., Shao, D.H. and Liang, Z.A., 1990. Frequency discrimination of a sine frequency modulator in guinea pigs. Chin. J. Physiol. Sci. 6, 156-165.

12. Shao, D.H., Lin, H.Y., Chen, G.D. and He, Z.Z., 1988. Slow cortical responses of auditory difference limes in macaca monkeys. Chin. J. Physiol. Sci. 4, 69-76.

11. Liang, Z.A., Shao, D.H. and Chen, G.D., 1988. Frequency discrimination of a sine amplitude modulator in guinea pig. Chin. J. Acoust. 6, 260-265.

10. Liang, Z.A., Chen, G.D. and Feng, J.M., 1988. Modulator pitch of a frequency-modulated carrier and its auditory resolution. Chin. J. Physiol. Sci. 4, 91-98.

9. Chen, G.D., Shao, D.H. and Liang, Z.A., 1988. Pitch discrimination of narrowband noise in guinea pigs. Chin. J. Acoust. 7, 266-272.

8. Chen, G.D., Shao, D.H. and Liang, Z.A., 1988. Perception and discrimination of modulator pitch. Third W. Pacif. Conf. on Acoust. 12, 1031-1034.

7. Chen, G.D., Yie, W.L., Tang, L.H. and Shao, D.H., 1987. A comprehensive study of the effect of intense noise on auditory functions. Inter-Noise 87, 1057-1060.

6. Yang, Q.H., Chen, G.D. and Liang, Z.A., 1986. Perception threshold of sound amplitude modulation. Acta Physiol. Sinica 38, 515-521.

5. Chen, G.D., 1986. Properties of otoacoustic emissions. Acoust. Progr. 5,31-36.

4. Liang, Z.A., Chen, G.D. and Lin, X., 1986. Spectral analyses of acoustic stimuli commonly applied in hearing measurements. Tech. Acoust. 5, 9-13.

3. Liang, Z.A., Chen, L., Zhu, M. and Chen, G.D., 1986. FM perception threshold of narrowband noise. Chin. J. Acoust. 5 (1), 80-86.

2. Chen, G.D. and Liang, Z.A., 1986. Pure tone FM-evoked responses from the medial geniculate body of guinea pig. Acta Physiol. Sinica 38, 42-48.

1. Liang, Z.A., Chen, G.D. and Feng, J.M., 1985. Auditory perception of frequency modulation of an amplitude modulator. Chin. J. Physiol. Sci. 1, 31-38.

 

Service:

Journal paper review
Ad hoc reviewer: Acta Oto-Laryngologica
Ad hoc reviewer: American Journal of Industrial Medicine
Ad hoc reviewer: Brain Research
Ad hoc reviewer: Clinica Chimica Acta
Ad hoc reviewer: Environmental Health Perspectives
Ad hoc reviewer: Healthy Aging & Clinical Care in the Elderly
Ad hoc reviewer: Hearing Research
Ad hoc reviewer: International Journal of Audiology
Ad hoc reviewer: Journal of Cellular and Molecular Medicine
Ad hoc reviewer: Medical Science Monitor
Ad hoc reviewer: Neuroscience
Ad hoc reviewer: Neuroscience Letter
Ad hoc reviewer: Neurotoxicity Research

Research grant review
Ad hoc reviewer: Health and Medical Research Fund. Food and Health Bureau, the Government of the Hong Kong Special Administrative Region, China