The primary mission of the Center for Hearing and Deafness is to conduct research. This mission is funded in large part by grants and contracts from government and private sources, as well as through support from the University.
|P.I.||Funding Source||Project Title/Focus||Funding Period|
|Benjamin Auerbach||NIH||Post-Doctoral Fellowship;The Role of Central Gain Control in Hyperacusis of Diverse Origin; This project proposes to identify the neural correlates of hyperacusis, a prominent sensory impairment in which everyday sounds are perceived as intolerably loud or painful. Behavioral and electrophysiological measures will be used to compare the mechanisms underlying hyperacusis associated with hearing loss or neurodevelopmental disruption and identify drugs that may ameliorate hyperacusis from these diverse backgrounds. The proposed studies will provide both clinical and basic science insights relevant to understanding and treating hyperacusis.||04/01/16 to 03/31/19|
|Kelly Radziwon ||Hearing Health Fndt. ||Noise-Induced Hyperacusis in Rats With and Without Hearing Loss; The goal of this study is to examine the physiological correlates of noise-induced hyperacusis in rats with |
significant high frequency hearing loss, and to identify the neural and behavioral changes that occur in rats
exposed to low level noise.
|07/01/18 to 06/30/19|
|Soroush Sadeghi||NIDCD||Differential Modulation of Response Properties of Vestibular Afferents by Cholinergic and GABAergic Efferents; The role of the rich vestibular efferent innervation, which provides feedback inputs from the brain stem to the vestibular peripheral sensory epithelia is not known. The present proposal uses a combination of immunohistochemistry, electrophysiology, and genetic approaches both in vitro and in vivo, to investigate changes in afferent response properties mediated by the different efferent pathways. Results will provide a better understanding of the function of the efferent vestibular system and the basis for new pharmacological approaches for improving compensation in patients with vestibular dysfunction.||12/01/15 to 11/30/19|
|Richard Salvi||Sub-Contract with Univ. of Florida (NIH)||Cochlear Detoxification System; The overall goal of this grant is to provide new basic knowledge of the molecular basis for the cochlear detoxification system and its role in the elimination of non-nutrient foreign chemicals and naturally occurring toxics throughout the lifespan.||04/01/15 to 03/31/20|
|Richard Salvi||NIDCD||Neural Basis of Hyperacusis; The goals of this project are to identify the neural correlates of tinnitus and hyperacusis and determine if the neural correlates have similar or different spectral and temporal profiles and if potassium channel modulators can suppress tinnitus and/or hyperacusis.||12/01/15 to 11/30/20|
|Richard Salvi||NIDCD||Hyperacusis and Central Gain; The overall goal of this project is to determine if Enhanced Central Gain can account for the spectral and temporal profile of hyperacusis and to determine if drugs that modulate serotonin and GABAergic neurotransmission can modulate behavioral measure of hyperacusis and Enhanced Central Gain in a similar fashion.||04/01/16 to 03/31/21 |