Currently Funded Projects

The primary mission of the Center for Hearing and Deafness is to conduct research. This mission is funded in large part by grants and contracts from government and private sources, as well as through support from the University.

P.I. Funding Source Project Title/Focus Funding Period
Benjamin Auerbach NIH Post-Doctoral Fellowship;The Role of Central Gain Control in Hyperacusis of Diverse Origin; This project proposes to identify the neural correlates of hyperacusis, a prominent sensory impairment in which everyday sounds are perceived as intolerably loud or painful. Behavioral and electrophysiological measures will be used to compare the mechanisms underlying hyperacusis associated with hearing loss or neurodevelopmental disruption and identify drugs that may ameliorate hyperacusis from these diverse backgrounds. The proposed studies will provide both clinical and basic science insights relevant to understanding and treating hyperacusis.   04/01/16 to 03/31/19
Senthilvelan Manohar Hearing Health Fndt.
Behavioral Model of Loudness Intolerance;  Primary objective of this grant is to develop and establish a reliable behavioral model to understand the pain and annoyance aspects of hyperacusis. 07/01/17 to 06/30/18
Jerome Roth / Richard Salvi NIOSH Occupational Exposure to Manganese and Noise Potentiate Hearing Loss; The goals of this project are to test the hypotheses that: (1) high doses of manganese alone cause hearing loss or cochlea pathology and (2) that high doses of manganese plus moderate noise exposure cause more hearing loss and cochlear pathology than either manganese alone or noise alone. 09/01/12 to 08/31/17
Soroush Sadeghi NIDCD Differential Modulation of Response Properties of Vestibular Afferents by Cholinergic and GABAergic Efferents; The role of the rich vestibular efferent innervation, which provides feedback inputs from the brain stem to the vestibular peripheral sensory epithelia is not known. The present proposal uses a combination of immunohistochemistry, electrophysiology, and genetic approaches both in vitro and in vivo, to investigate changes in afferent response properties mediated by the different efferent pathways. Results will provide a better understanding of the function of the efferent vestibular system and the basis for new pharmacological approaches for improving compensation in patients with vestibular dysfunction. 12/01/15 to 11/30/18
Soroush Sadeghi American Otological Society, Inc. In Vivo Stimulation of Vestibular Nerve Afferents and Efferents. Modulation of auditory and vestibular afferents by optogenetic stimulation of efferents in vivo. The experiments in this proposal aim at specifically studying the differential modulation of auditory and vestibular afferent nerve fibers in response to stimulation of cholinergic and GABAergic efferent pathways. We use new approaches and techniques in order to investigate these pathways and their ionotropic and metabotropic pathways separately.
07/01/16 to 06/30/17
Richard Salvi NIDCD

Blast Wave Effects: Hearing, Memory, Therapy; The goals of this project are to determine: (1) if blast wave injury induces necrotic and/or apoptotic cell death in the cochlea, (2) if blast wave exposure leads to cell death in the hippocampus, suppresses neurogenesis and lead to memory impairments, (3) if anti-oxidant therapy can prevent cell death in the cochlea and preserve hearing function and (4) if antioxidant therapy can prevent cell death in the hippocampus and prevent memory impairments.

07/01/12 to 06/30/18
Richard Salvi Sub-Contract with Univ. of Florida (NIH) Cochlear Detoxification System; The overall goal of this grant is to provide new basic knowledge of the molecular basis for the cochlear detoxification system and its role in the elimination of non-nutrient foreign chemicals and naturally occurring toxics throughout the lifespan. 04/01/15 to 03/31/20
Richard Salvi NIDCD Neural Basis of Hyperacusis; The goals of this project are to identify the neural correlates of tinnitus and hyperacusis and determine if the neural correlates have similar or different spectral and temporal profiles and if potassium channel modulators can suppress tinnitus and/or hyperacusis. 12/01/15 to 11/30/20
Richard Salvi NIDCD Hyperacusis and Central Gain; The overall goal of this project is to determine if Enhanced Central Gain can account for the spectral and temporal profile of hyperacusis and to determine if drugs that modulate serotonin and GABAergic neurotransmission can modulate behavioral measure of hyperacusis and Enhanced Central Gain in a similar fashion. 04/01/16 to 03/31/21
Gail Seigel Childhood Cancer Trust Targeted Antibody-Drug Conjugates for Retinoblastoma Therapy; The goal of this project is to develop new antibody-directed therapies for retinoblastoma, a childhood tumor of the eye. These new therapies are designed to be less toxic and more specific to tumor cells in order to preserve vision and quality of life for young retinoblastoma patients. To be announced
Adam Sheppard
NIDCD Predoctoral Fellowship; Synaptopathy and Neural Gain Following Low-Level Noise Exposure;  08/15/16 to 07/31/17
Adam Sheppard American Academy of Audiology Physiological Effects of Low-Level Sound Used for Tinnitus and Hyperacusis Therapy;
09/01/16 to 08/31/17