Glucocorticoids are a class of steroid hormone which regulate systemic gluconeogenesis. In addition, glucocorticoids are potent suppressors of immune system function. Synthetic glucocorticoids are widely used clinically as immunosuppressant and anti-inflammatory drugs. However, many of the side-effects of these agents result from their gluconeogenic effects on muscle, liver, kidney, and adipose tissue. A primary mechanism of action of glucocorticoids involves modulation of gene expression. The goal of our work is to apply a pharmacodynamic approach to glucocorticoid modulation of gene expression at the transcriptional and translational levels. A primary focus concerns the role of receptor autoregulation in steroid response to various steroid dosing regimens.