Debra C. DuBois

PhD

Debra C. DuBois.

Debra C. DuBois

PhD

Debra C. DuBois

PhD

Adjunct Research Associate Professor

Research Interests

Molecular Dynamics of Steroid Action

Contact Information

117 Hochstetter Hall

Buffalo NY, 14260

Phone: (716) 645-4907

dubois@nsm.buffalo.edu

Education

  • PhD, University at Buffalo

Research Summary

Glucocorticoids are a class of steroid hormone which regulate systemic gluconeogenesis. In addition, glucocorticoids are potent suppressors of immune system function. Synthetic glucocorticoids are widely used clinically as immunosuppressant and anti-inflammatory drugs. However, many of the side-effects of these agents result from their gluconeogenic effects on muscle, liver, kidney, and adipose tissue. A primary mechanism of action of glucocorticoids involves modulation of gene expression. The goal of our work is to apply a pharmacodynamic approach to glucocorticoid modulation of gene expression at the transcriptional and translational levels. A primary focus concerns the role of receptor autoregulation in steroid response to various steroid dosing regimens.

Selected Publications