I have now spent a decade working with colleagues to understand Dengue virus transmission in Thailand. The goal is to predict disease dynamics under changing environmental constraints and to inform disease reduction strategies that are appropriate for local circumstances. I have developed spatial sampling procedures that enable observation of key components of the process including active infections, infectious mosquitoes, and cases across the clinical spectrum. These techniques have supported novel research in entomology, virology, immunology, and epidemiology. Spatial analysis techniques have provided key insights into the transmission process. Local heterogeneity in infection risk is striking and plays a key role in the pattern of illness and hospitalization. I am currently developing individual-level simulation models of dengue transmission to assess the impact of vaccine roll out.