Each thought that crosses your mind is carried along the network of billions of interconnected neurons that make up your brain. The manner in which those neurons are connected shapes how you think: Learning a skill can build up connections between one set of brain regions, but brain disease that disconnects a different set of brain areas can cause you to believe your mother is an imposter! I use behavioral studies, neuroimaging (fMRI) and machine learning to investigate relationships between the mind and the brain’s wiring. I focus especially on behaviors like reading that depend on communication between functionally-specialized brain regions. Recent neuroimaging studies in my lab have produced biologically plausible simulations of knowledge deficits following stroke and shown that the brain’s wiring can diagnose ADHD with almost perfect accuracy. An accidental discovery in the last year showed that the manner in which strong and poor reader’s brains organize as they learn to read can even influence how their brain carries out mental math, providing an intriguing explanation for why children with reading difficulty are more likely to also have a math disability.