Robert A. Coburn

PhD

Robert A. Coburn

PhD

Contact Information

Education

  • PhD, Harvard University, 1966
  • BS, Akron University, 1960

History and Overview of Interests

Professor Coburn retired in 2004. Professor Coburn’s research focused on drug discovery in the areas of topical anti-microbial and anti-inflammatory agents, as well as agents for reversing multi-drug resistance in cancer and other infectious diseases.

Specializations

Antimicrobial & Anti-inflammatory Agents, Combinatorial Chemistry, Drug Design & Discovery, Chemosensitisers for Multidrug Resistance.

Selected Publications

  • T. Clark and R.A. Coburn, 5-Alkylsulfonylsalicylanilides as Potential Dental Plaque Agents, J. Med. Chem. l986, 29, 25.
  • A. Coburn, M. Wierzba, M.J. Suto, A.J. Solo, D.J. Triggle, l,4-Dihydropyridine Antagonist Activities at the Calcium Channel: A Quantitative Structure-Activity Relationship Approach, J. Med. Chem. l988, 31, 2l03-2l07.
  • A. Coburn, QSAR-PC:PAR, A Microcomputer Program for Drug Design, BIOSOFT, Cambridge, U.K., l989.
  • K. Anderson, R. A. Coburn, T. Gopalsamy and T. J. Howe, “A Facile Selective Acylation of Castanospermine,” Tet. Lett., 1990, 31, 169.
  • P. Mager, R. A. Coburn, A. J. Solo, D. J. Triggle and H. Rothe, “QSAR, Diagnostic Statistics and Molecular Modeling of 1,4-Dihydropyridine Calcium Antagonists: A Difficult Road Ahead,” Drug Design Disc. 1992, 8, 273-289.