Bo-Hua Hu, Ph.D.,CCC-A

e-mail: bhu@buffalo.edu

Tel: 716-829-5316

Professional Positions:

Associate Professor           
     Department of Communicative Disorders and Sciences, University at Buffalo 
Res. Assistant Professor  
     Center for Hearing and Deafness, University at Buffalo
Associate Professor          
      Institute of Otolaryngology, Chinese PLA General Hospital 
Assistant Professor 
     Institute of Otolaryngology, Chinese PLA General Hospital 
Otolaryngologist             
     Dept. of Otolaryngology, Chinese PLA General Hospital

Education:

Ph.D. in Communicative Disorders and Sciences 
      University at Buffalo 
M.A. in Audiology
     University at Buffalo 
Ph.D. in Otolaryngology
     Postgraduate Medical School of PLA, Beijing
M.A. in Otolaryngology
     Postgraduate Medical School of PLA, Beijing
M.D. in Medical Science
     Second Military Medical University, Shanghai

Publications 

Frye, M.D., Yang, W., Zhang, C., Xiong, B., Hu, B.H. 2016. Dynamic activation of basilar membrane macrophages in response to chronic sensory cell degeneration in aging mouse cochleae. Hearing Research.

Vethanayagam, R.R., Yang, W., Dong, Y., Hu, B.H. 2016. Toll-like receptor 4 modulates the cochlear immune response to acoustic injury. Cell Death Dis 7, e2245.

Wang, D., Xiong, B., Xiong, F., Chen, G.-D., Hu, B.H., Sun, W. 2016. Apical hair cell degeneration causes the increase in the amplitude of summating potential. Acta Oto-Laryngologica, 1-6.

Yang, S.Z., Cai, Q.F., Vethanayagam, R.R., Wang, J.M., Yang, W.P., Hu, B.H. 2016. Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic trauma. Hearing Research 333, 283-294.

Guo, Z., Tzvetkova, B., Bassik, J.M., Bodziak, T., Wojnar, B.M., Qiao, W., Obaida, M.A., Nelson, S.B., Hu, B.H., Yu, P. 2015. RNASeqMetaDB: a database and web server for navigating metadata of publicly available mouse RNA-Seq datasets. Bioinformatics 31, 4038-40.

Wang, B., Hu, B., Yang, S. 2015. Cell junction proteins within the cochlea: A review of recent research. Journal of Otology 10, 131-135.

Yang, S.Z., Cai, Q.F., Bard, J., Jamison, J., Wang, J.M., Yang, W.P., Hu, B.H. 2015a. Variation analysis of transcriptome changes reveals cochlear genes and their associated functions in cochlear susceptibility to acoustic overstimulation. Hearing Research 330, 78-89.

Yang, W., Vethanayagam, R.R., Dong, Y., Cai, Q., Hu, B.H. 2015b. Activation of the antigen presentation function of mononuclear phagocyte populations associated with the basilar membrane of the cochlea after acoustic overstimulation. Neuroscience 303, 1-15.

Cai, Q., Vethanayagam, R.R., Yang, S., Bard, J., Jamison, J., Cartwright, D., Dong, Y., Hu, B.H. 2014a. Molecular profile of cochlear immunity in the resident cells of the organ of Corti. Journal of Neuroinflammation 11, 173.

Cai, Q., Wang, B., Coling, D., Zuo, J., Fang, J., Yang, S., Vera, K., Hu, B.H. 2014b. Reduction in noise-induced functional loss of the cochleae in mice with pre-existing cochlear dysfunction due to genetic interference of prestin. PloS one 9, e113990.

Cai, Q., Wang, B., Patel, M., Yang, S.M., Hu, B.H. 2013a. RNAlater facilitates microdissection of sensory cell-enriched samples from the mouse cochlea for transcriptional analyses. J Neurosci Methods 219, 240-51.

Cai, Q., Whitcomb, C., Eggleston, J., Sun, W., Salvi, R., Hu, B.H. 2013b. Round window closure affects cochlear responses to suprathreshold stimuli. Laryngoscope 123.

Hu, B.H. 2013. High-Throughput Technologies for Gene Expression Analyses: What We Have Learned for Noise-Induced Cochlear Degeneration. Journal of Otology 8, 25-31.

Patel, M., Cai, Q., Ding, D., Salvi, R., Hu, Z., Hu, B.H. 2013a. The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma. PloS one 8, e58471.

Patel, M., Hu, Z., Bard, J., Jamison, J., Cai, Q., Hu, B.H. 2013b. Transcriptome characterization by RNA-Seq reveals the involvement of the complement components in noise-traumatized rat cochleae. Neuroscience 248C, 1-16.

Yang, W.P., Xu, Y., Guo, W.W., Liu, H.Z., Hu, B.H. 2013. Modulation of Mcl-1 expression reduces age-related cochlear degeneration. Neurobiol Aging.

Cai, Q., Patel, M., Coling, D., Hu, B.H. 2012. Transcriptional changes in adhesion-related genes are site-specific during noise-induced cochlear pathogenesis. Neurobiology of disease 45, 723-32.

Hu, B. 2012. Noise-Induced Structural Damage to the Cochlea. In: Le Prell, C.G., Henderson, D., Fay, R.R., Popper, A.N., (Eds.), Noise-Induced Hearing Loss - Scientific Advances, Vol. 40. Springer New York. pp. 57-86.

Hu, B.H., Cai, Q., Hu, Z., Patel, M., Bard, J., Jamison, J., Coling, D. 2012. Metalloproteinases and their associated genes contribute to the functional integrity and noise-induced damage in the cochlear sensory epithelium. J Neurosci 32, 14927-41.

Patel, M., Hu, B.H. 2012. MicroRNAs in inner ear biology and pathogenesis. Hear Res 287, 6-14.

Tanaka, C., Coling, D.E., Manohar, S., Chen, G.D., Hu, B.H., Salvi, R., Henderson, D. 2012. Expression pattern of oxidative stress and antioxidant defense-related genes in the aging Fischer 344/NHsd rat cochlea. Neurobiol Aging 33, 1842.e1-1842.e14.

Yang, W.P., Guo, W.W., Liu, H.Z., Xu, Y., Chen, L., Hu, B.H. 2012. Age-related changes in the ratio of Mcl-1/Bax expression in the rat cochlea. Acta Otolaryngol 132, 123-32.

Zheng, G., Hu, B.H. 2012. Cell-cell junctions: a target of acoustic overstimulation in the sensory epithelium of the cochlea. BMC neuroscience 13, 71.

Jamesdaniel, S., Hu, B., Kermany, M.H., Jiang, H., Ding, D., Coling, D., Salvi, R. 2011. Noise induced changes in the expression of p38/MAPK signaling proteins in the sensory epithelium of the inner ear. Journal of proteomics 75, 410-24.

Hu, B.H., Cai, Q. 2010. Acoustic overstimulation modifies Mcl-1 expression in cochlear sensory epithelial cells. J Neurosci Res 88, 1812-21.

Yang, W.P., Hu, B.H., Sun, J.H., Zhai, S.Q., Henderson, D. 2010. Death mode-dependent reduction in succinate dehydrogenase activity in hair cells of aging rat cochleae. Chinese medical journal 123, 1633-8.

Chen, G.D., Li, M., Tanaka, C., Bielefeld, E.C., Hu, B.H., Kermany, M.H., Salvi, R., Henderson, D. 2009. Aging outer hair cells (OHCs) in the Fischer 344 rat cochlea: function and morphology. Hear Res 248, 39-47.

Hu, B.H. 2009. Mechanisms of noise-induced hair cell death. The ASHA Leader 14, 5-6.

Hu, B.H., Cai, Q., Manohar, S., Jiang, H., Ding, D., Coling, D.E., Zheng, G., Salvi, R. 2009. Differential expression of apoptosis-related genes in the cochlea of noise-exposed rats. Neuroscience 161, 915-925.

Tanaka, C., Chen, G.D., Hu, B.H., Chi, L.H., Li, M., Zheng, G., Bielefeld, E.C., Jamesdaniel, S., Coling, D., Henderson, D. 2009a. The effects of acoustic environment after traumatic noise exposure on hearing and outer hair cells. Hear Res 250, 10-8.

Tanaka, C., Chen, G.D., Hu, B.H., Salvi, R., Henderson, D. 2009b. Changes in E-cadherin in the cochlea after traumatic noise exposure. 32th Annual MidWinter Meeting of Assoc. Res. Otolaryngol. Baltimore, MD.

Yang, W.P., Hu, B.H., Chen, G.D., Bielefeld, E.C., Henderson, D. 2009. Protective effect of N-acetyl-L-cysteine (L-NAC) against styrene-induced cochlear injuries. Acta Otolaryngol, 1036-1043.

Bielefeld, E.C., Coling, D., Chen, G.D., Li, M., Tanaka, C., Hu, B.H., Henderson, D. 2008. Age-related hearing loss in the Fischer 344/NHsd rat substrain. Hear Res 241, 26-33.

Henderson, D., Hu, B.H., Bielefeld, E. 2008. Pattern and Mechanisms of Noise-Induced Cochlear Pathology. In: Schacht, J., Nppper, A.N., Fay, R.R., (Eds.), Auditory Trauma, Protection, and Repair. Springer, New York. pp. 195-217.

Hu, B.H., Henderson, D., Yang, W.P. 2008a. The impact of mitochondrial energetic dysfunction on apoptosis in outer hair cells of the cochlea following exposure to intense noise. Hear Res 236, 11-12.

Hu, B.H., Yang, W.P., Bielefeld, E.C., Li, M., Chen, G.D., Henderson, D. 2008b. Apoptotic outer hair cell death in the cochleae of aging Fischer 344/NHsd rats. Hear Res 245, 48-57.

Hu, B.H., Zheng, G.L. 2008c. Membrane disruption: An early event of hair cell apoptosis induced by exposure to intense noise. Brain Res 1239, 107-18.

Hu, B.H. 2007. Delayed mitochondrial dysfunction in apoptotic hair cells in chinchilla cochleae following exposure to impulse noise. Apoptosis 12, 1025-36.

Harris, K.C., Bielefeld, E., Hu, B.H., Henderson, D. 2006. Increased resistance to free radical damage induced by low-level sound conditioning. Hear Res 213, 118-29.

Henderson, D., Bielefeld, E.C., Harris, K.C., Hu, B.H. 2006. The Role of Oxidative Stress in Noise-Induced Hearing Loss. Ear Hear 27, 1-19.

Hu, B.H., Henderson, D., Bielefeld, E.C., Harris, K.C., Fetoni, A.R., Nicotera, T. 2006a. RETRACTED: Prevention of hearing loss from noise exposure using Src inhibitors. Hear Res.

Hu, B.H., Henderson, D., Nicotera, T.M. 2006b. Extremely rapid induction of outer hair cell apoptosis in the chinchilla cochlea following exposure to impulse noise. Hear Res 211, 16-25.

Bielefeld, E.C., Hu, B.H., Harris, K.C., Henderson, D. 2005. Damage and threshold shift resulting from cochlear exposure to paraquat-generated superoxide. Hear Res 207, 35-42.

Harris, K.C., Hu, B., Hangauer, D., Henderson, D. 2005. Prevention of noise-induced hearing loss with Src-PTK inhibitors. Hear Res 208, 14-25.

Yang, W.P., Henderson, D., Hu, B.H., Nicotera, T.M. 2004. Quantitative analysis of apoptotic and necrotic outer hair cells after exposure to different levels of continuous noise. Hear Res 196, 69-76.

Hu, B.H., Henderson, D., Nicotera, T.M. 2003. Progression of outer hair cell death in the chinchilla cochlea following traumatic noise exposure. Seminars in Hearing 24, 111-114.

Nicotera, T.M., Hu, B.H., Henderson, D. 2003. The caspase pathway in noise-induced apoptosis of the chinchilla cochlea. J Assoc Res Otolaryngol 4, 466-77.

Hu, B.H., Henderson, D., Nicotera, T.M. 2002a. F-actin cleavage in apoptotic outer hair cells in chinchilla cochleas exposed to intense noise. Hear Res 172, 1-9.

Hu, B.H., Henderson, D., Nicotera, T.M. 2002b. Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise. Hear Res 166, 62-71.

Yang, W.P., Guo, W., Hu, B.H., Hu, Y.Y., Wang, P.Y., Yang, W.Y. 2002a. Noise induced morphological changes in the hair cell nucleus of the guinea pig cochlea. Med J Chin PLA 27, 152-3.

Yang, W.P., Hu, Y.Y., Hu, B.H., Guo, W., Yang, W.Y. 2002b. Glial cell line-derived neurotrophic factor and neurotrophin-3 protect hair cell from exposure to traumatic noise: observation of the nuclear morphology. Med J Chin PLA 27, 1048-9.

Hu, B.H., Nicotera, T., Henderson, D. 2001. The temporal and spatial progression of apoptosis and its caspase-3 pathway in chinchilla cochlea exposed to intense noise. Poster presented at Association for Research in Otolaryngology, St. Petersburg Beach, FL.

Nicotera, T., Henderson, D., Hu, B.H., Zheng, X.Y. 2001. Noise exposure and mechanisms of hair cell death. In: Henderson, D., Prasher, D., Kopke, R., Salvi, R., Hamernik, R., (Eds.), Noise Induced Hearing Loss: Basic Mechanisms, Prevention and Control. Noise Research Network Publications, London. pp. 99-117.

Yang, W.P., Hu, B., Guo, W., Hu, Y., Wang, P., Jiang, S. 2001. [Synergetic protective effects of glial cell line-derived neurotrophic factor combined with neurotrophin-3 in F-actin on hair cell after noise trauma]. Zhonghua er bi yan hou ke za zhi 36, 342-5.

Zou, Y., Huang, D., Hu, B., Zhai, S., Fang, Y. 2001. [The role of fibrinolysis in pathogenesis of middle ears adhesions]. Zhonghua er bi yan hou ke za zhi 36, 357-9.

Hu, B.H., Guo, W., Wang, P.Y., Henderson, D., Jiang, S.C. 2000. Intense noise-induced apoptosis in hair cells of guinea pig cochleae. Acta Otolaryngol 120, 19-24.

Henderson, D., Hu, B., McFadden, S., Zheng, X. 1999. Evidence of a Common Pathway in Noise-Induced Hearing Loss and Carboplatin Ototoxicity. Noise Health 2, 53-70.

Hu, B.H., McFadden, S.L., Salvi, R.J., Henderson, D. 1999. Intracochlear infusion of buthionine sulfoximine potentiates carboplatin ototoxicity in the chinchilla. Hear Res 128, 125-34.

Jacono, A.A., Hu, B., Kopke, R.D., Henderson, D., Van De Water, T.R., Steinman, H.M. 1998. Changes in cochlear antioxidant enzyme activity after sound conditioning and noise exposure in the chinchilla. Hear Res 117, 31-8.

Hu, B.H., Henderson, D. 1997a. Changes in F-actin labeling in the outer hair cell and the Deiters cell in the chinchilla cochlea following noise exposure. Hear Res 110, 209-18.

Hu, B.H., Zheng, X.Y., McFadden, S.L., Kopke, R.D., Henderson, D. 1997b. R-phenylisopropyladenosine attenuates noise-induced hearing loss in the chinchilla. Hear Res 113, 198-206.

Zheng, X.Y., Henderson, D., Hu, B.H., Ding, D.L., McFadden, S.L. 1997a. The influence of the cochlear efferent system on chronic acoustic trauma. Hear Res 107, 147-59.

Zheng, X.Y., Henderson, D., Hu, B.H., McFadden, S.L. 1997b. Recovery of structure and function of inner ear afferent synapses following kainic acid excitotoxicity. Hear Res 105, 65-76.

Zheng, X.Y., Henderson, D., McFadden, S.L., Hu, B.H. 1997c. The role of the cochlear efferent system in acquired resistance to noise-induced hearing loss. Hear Res 104, 191-203.

Hu, B.H., Jiang, S.C. 1995. Effect of focal cochlear vascular lesion on endocochlear potential in guinea pigs. Hear Res 89, 69-75.

Streit, W.J., Graeber, M.B., Kreutzberg, G.W. 1988. Functional plasticity of microglia: a review. Glia 1, 301-7.

BOOK CHAPTERS

Hu, B.H. 2011. Noise-induced structural damage to the cochlea. In: Popper, A.N., Fay, R.R., Henderson, D., Prell, C.L., (Eds), Springer Handbook of Auditory Research, Noise Induced Hearing Loss: Scientific Advances. Springer Science, New York. pp. 57-86.

Henderson, D., Hu, B.H., Bielefeld E. (2008) Patterns and Mechanisms of Noise-induced Cochlear Pathology. In Schacht, J., Popper, A.N. and Fay R.R. (Eds.), Auditory Trauma, Protection, and Repair. Springer. pp. 195-217.

Henderson, D., Hu, B.H., Bielefeld E., Nicotera, T.M. (2006) Cellular mechanisms of noise-induced hearing loss. In Campbell, K (Ed.), Pharmacology and Ototoxicity for Audiologists. Thomson Delmar Learning, pp. 216-229.

Hu, B.H., Henderson, D., Nicotera, T.M. (2003). Progression of outer hair cell death in the chinchilla cochlea following traumatic noise exposure. In: Simmons, D.D., Palmer, C., (Eds.), Seminars in Hearing.  New Frontiers in the Amelioration of Hearing Loss: Part 2 Hair Cell Development, Regeneration, Protection, and Rescue, Vol. 24. Theime Medical Publishers, New York. pp. 111-114.

Hu, B.H., Henderson, D., Liu, C.C., Zheng, X.Y., McFadden, S.L., Nicotera, T.M., Hight, N.G. (2001). Protection from impulse noise with R-PIA is dependent on the level of the noise and the duration of the treatment. In: Henderson, D., Prasher, D., Kopke, R., Salvi, R.J., Hamernik, R.P., (Eds.), Noise Induced Hearing Loss: Basic Mechanisms, Prevention and Control, 1st ed. Noise Res. Network Publications (nRn), London. pp. 203-213.

Nicotera, T.M., Henderson, D., Hu, B.H., Zheng, X.Y. 2001. Noise exposure and mechanisms of hair cell death. In: Henderson, D., Prasher, D., Kopke, R., Salvi, R.J., Hamernik, R.P., (Eds.), Noise Induced Hearing Loss: Basic Mechanisms, Prevention and Control, 1st ed. Noise Res. Network Publications (nRn), London. pp. 99-117.