Our research is dedicated to investigating the biological and molecular mechanisms underlying acquired hearing loss. Specifically, we focus on several types of hearing loss, including that caused by acoustic trauma, age-related auditory degeneration, and genetic factors. We are particularly interested in understanding the mechanisms of hair cell death, the role of immune and inflammatory processes in the cochlea, and the ways in which auditory homeostasis and cochlear responses to pathological conditions differ between males and females.
- Zhang, C., Frye, M.D., Riordan, J., Sharma, A., Manohar, S., Salvi, R., Sun, W., Hu, B.H., 2021. Loss of CX3CR1 augments neutrophil infiltration into cochlear tissues after acoustic overstimulation. Journal of Neuroscience Research.
- Zhang, C., Frye, M.D., Sun, W., Sharma, A., Manohar, S., Salvi, R., Hu, B.H. 2020. New insights on repeated acoustic injury: Augmentation of cochlear susceptibility and inflammatory reaction resultant of prior acoustic injury. Hear Res 393, 107996.
- Dong, Y., Zhang, C., Frye, M., Yang, W., Ding, D., Sharma, A., Guo, W., Hu, B.H. 2018. Differential fates of tissue macrophages in the cochlea during postnatal development. Hear Res 365, 110-126.
- Frye, M.D., Zhang, C., Hu, B.H. 2018. Lower-level noise exposure that produces only TTS modulates the immune homeostasis of cochlear macrophages. Journal of Neuroimmunology 323, 152-166.
- Hu, B.H., Zhang, C., Frye, M.D. 2018. Immune cells and non-immune cells with immune function in mammalian cochleae. Hear Res 362, 14-24.
For a list of all publications, see Google Scholar profile.