Published September 2, 2021
The Genetics Society of America (GSA) announced the appointment of Laura Rusche, PhD, as associate editor on the editorial board of its journal, GENETICS, in the Gene Expression Section. Since 1916, GENETICS has published high–quality, original research presenting novel findings bearing on genetics and, more recently, genomics. The journal publishes empirical studies of organisms ranging from microbes to humans, as well as theoretical work. Rusche has published several of her own papers in GENETICS and says she is honored to be selected for this editorial position. Rusche looks forward to helping colleagues share their studies on gene expression. Read GSA's announcement, here.
Chromatin and its impact on gene expression and chromosome function; Gene duplication and the evolution of protein functions; Rewiring of transcriptional circuits.
Buffalo NY, 14260
Phone: (716) 645-5198
Fax: (716) 645-2975
The Rusche Lab studies chromatin and its impact on gene expression and chromosome function. We also study how protein functions shift over evolutionary time through mechanisms including gene duplication and rewiring of transcriptional circuits. In our studies, we gain an evolutionary perspective by comparing multiple yeast species, taking advantage of the genome editing and comparative genomic approaches available for these species. One arm of our research program focuses on Sir2 proteins (sirtuins), which deacetylate histones to repress transcription. Because sirtuins require NAD+ for activity, they are thought to link the processes they regulate with nutrient availability. We are investigating how the functions of yeast sirtuins have shifted over the course of evolution to enable species to develop distinct responses to low NAD+ stress. Another arm of our research focuses on the nucleosome-binding protein Sir3, which partners with Sir2 to form heterochromatin. We are reconstructing the steps by which Sir3 evolved from the conserved replication protein Orc1 through gene duplication, subfunctionalization, and specialization.