Anatomical and biochemical basis of ingestive behaviors, including food, water, and salt intake.
Research in my laboratory focuses on the neural mechanisms involved in the control of drinking and eating. Thirst and hunger are critical drives that ensure animals maintain appropriate levels of hydration and energy, respectively. Disruptions in fluid and energy homeostasis are associated with a variety of disease states including, but not limited to, hypertension and obesity. Two specific areas of interest include: 1) understanding the separate but overlapping circuits that control hunger and thirst, especially with respect to the role played by glucagon-like peptide-1 in drinking and feeding; and 2) using the enhanced response to repeated bouts of thirst as a model system to understand circuits that incorporate learning into the control of ingestive behavior.
Parsing the central control of thirst and hunger using a rat model of diabetes insipidus, National Institutes of Health (NIDDK), 8/17/2022 – 5/31/2026, $2,117,234