Soo-Kyung Lee’s long-term goals are to dissect gene regulatory events that lead to the cellular diversity and eventually formation of functional neural circuits in the CNS and to understand genetic and mechanistic basis for neurodevelopmental defects, ultimately contributing to the generation of better treatment strategies for human developmental disorders.
Over the past decade, Lee has pioneered biochemical and molecular approaches in mouse and chick embryos to unravel the fundamental principles controlling gene expression and cell fate specification in the developing CNS. This led to a series of seminal discoveries into the gene regulatory network required for neuronal fate specification.
More recently, Lee has begun dissecting a human autism disorder FoxG1 syndrome, characterized by severe deficits in cortex development along with other life-threatening symptoms. Soo is devoted to understanding the FoxG1 biology and also engaged in translational research to find a cure for the disorder.
|Construction and characterization of humanized FoxG1 mouse models||FoxG1 Research Foundation||Jae Lee||July 1, 2020-June 30, 2023||$400,000 a year|
|Molecular dissection of forebrain developmental deficits caused by mutations in human FoxG1 syndrome||FoxG1 Research Foundation||Soo Lee||July 1, 2020-June 30, 2023||$200,000 a year|
|Transcriptional regulators of motor columnar specification||NINDS/NIH||Soo Lee||04/01/2019 – 03/31/2024||$2,494,667|
|FoxG1-directed Gene network in forebrain development and FoxG1 syndrome||NINDS/NIH||Soo Lee||6/01/2017 – 04/30/2022 ||$2,412,778|
|Roles Of Mll4-Complex In Development Of Hypothalamic Arcuate Neurons||NIDDK/NIH||Jae Lee||July 1, 2020-June 30, 2021||$81,001|
|Transcription Factors Governing The Development Of Ghrh-Neurons||NINDS/NIH||Jae Lee||July 1, 2020-June 30, 2021||$558,250|