PBS cites research by Vincent Lynch to better understand elephantoid genome
The Woolly Mammoth always attracts attention, which is why PBS Digital Studios explores How To Build A Woolly Mammoth (But Should We?) Presented by PBS Eons, host Blake de Pastino observes, "In the quest to understand how evolution basically built the woolly mammoth, we may have found the blueprints for building them ourselves." Vincent Lynch's research on elephantoid genome is cited throughout the episode. View the video, here.
Faculty Profile
![Vincent J. Lynch, PhD.]()
Vincent J. Lynch
PhD
Research Interests
Genetics, Genomics and Systems Biology; Evolutionary Biology.
Education
PhD, Ecology and Evolutionary Biology, Yale University, 2008
MS, Ecology and Evolutionary Biology, Yale University, 2005
BS, Biology and Anthropology, University at Albany, SUNY, 2002
Office Hours
Contact vjlynch@buffalo.edu
Research Summary
A major challenge in biology is to determine the genetic and molecular mechanisms responsible for phenotypic differences between species (DevoEvo), particularly mechanisms that underlie the origin of new anatomical structures (‘evolutionary novelties’), biological functions (‘evolutionary innovations’), and that limit biological possibilities (‘developmental constraints’). To explore how evolutionary novelties, innovations, and developmental constraints evolve we combine comparative genomics and experimental methods to deduce the molecular mechanisms that underlie the evolution of pregnancy and animals with extremely long lifespans and large body sizes, and the role evolutionary history plays in our susceptibility to diseases such as preterm birth and cancer.
Current Project
Evolutionary mechanics of adhesion complexes that mediate Amniote hearing
Selected Publications
- VJ Lynch Relaxed constraint and functional divergence of the progesterone receptor (PGR) in the human stem-lineage M Marinić, , PLoS Genetics 16 (4), e1008666
- E Fry, SK Kim, S Chigurapti, KM Mika, A Ratan, A Dammermann, Brian J. Mitchell, Webb Miller, Vincent J Lynch (2020) Functional architecture of deleterious genetic variants in the genome of a Wrangel Island mammoth. Genome Biology and Evolution 12 (3), 48-58
- JM Vazquez, VJ Lynch. Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk. bioRxiv
- M Marinic, K Mika, S Chigurupati, VJ Lynch, Evolutionary transcriptomics implicates HAND2 in the origins of implantation and regulation of gestation length. bioRxiv
- Erin Fry, Sun K. Kim, Sravanthi Chigurapti, Katelyn M. Mika, Aakrosh Ratan, Alexander Dammermann, Brian J. Mitchell, Webb Miller, Vincent J. Lynch (2020) Functional architecture of deleterious genetic variants in the genome of a Wrangel Island mammoth. Genome Biology and Evolution, evz279.
- Vazquez JM, Sulak M, Chigurupati S, Lynch VJ (2018) A Zombie LIF Gene in Elephants Is Upregulated by TP53 to Induce Apoptosis in Response to DNA Damage. Cell Rep. 24(7):1765-1776.
- Sulak M, Fong L, Mika K, Chigurupati S, Yon L, Mongan NP, Emes RD, Lynch VJ (2016) TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. Elife. 5: e11994.
- Lynch VJ, Nnamani MC, Kapusta A, Brayer K, Plaza SL, Mazur EC, Emera D, Sheikh SZ, Grützner F, Bauersachs S, Graf A, Young SL, Lieb JD, DeMayo FJ, Feschotte C, Wagner GP (2015) Ancient transposable elements transformed the uterine regulatory landscape and transcriptome during the evolution of mammalian pregnancy. Cell Rep. 10(4):551-61.
