Qing Lin

PhD

Qing Lin.

Qing Lin

PhD

Qing Lin

PhD

Research Interests

Bioorganic and medicinal chemistry: Bioorthogonal chemistry/organic reactions in living systems, bioorthogonal reaction discovery and development, peptide/protein therapeutics, synthetic biology

Contact Information

679 Natural Sciences Complex

Buffalo NY, 14260

Phone: (716) 645-4254

Fax: (716) 645-6963

qinglin@buffalo.edu

Education

  • Damon Runyon Cancer Research Foundation Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA, 2000-2003
  • PhD, Yale University, 2000
  • MS, University of Pittsburgh, 1997
  • BS, University of Science and Technology of China, 1994

Awards and Honors

  • SUNY Chancellor’s Award for Excellence in Scholarship and Creative Activities, 2020
  • NIH/NIGMS Maximizing Investigators' Research Award, 2019
  • Japan Society for the Promotion of Science (JSPS) Fellowship, 2013
  • National Academies Keck Future Initiatives in Synthetic Biology Grant Award, 2010

Research Summary

Our research program aims to develop and apply new chemical tools and principles to solve biological problems that are difficult to solve, if not impossible, by standard biological techniques. A central theme of our research is to harness the power of organic reactions to study protein dynamics, function, and assembly in living systems. We are currently working in the following three areas:

  1. Develop bioorthogonal reactions as a tool to study protein function in various cellular systems;
  2. Develop new enabling technologies for translating peptides into cancer therapeutics;
  3. Design nano-sized bioreactors for sustainable production of pharmaceuticals.

Please check our group page for details.

Selected Recent Publications

Google Scholar Profile Link

  • Yulin Tian and Qing Lin* “Fitness Factors for Bioorthogonal Chemical Probes” ACS Chem. Biol. 2019, 14, 2489-2496.
  • Yulin Tian, Huafei Zou, Peng An, Zhihong Zhou, Weijun Shen,* and Qing Lin,* “Design and Synthesis of Stapled Oxyntomodulin Analogs Containing Functionalized Biphenyl Cross-Linkers” Tetrahedron 2019, 75, 286-295.
  • Peng An, Hsuan-yi Wu, Tracey M. Lewandowski, and Qing Lin* “Hydrophilic azaspiroalkenes as robust bioorthogonal reporters” Chem. Comm. 2018, 54, 14005-14008.
  • Peng An and Qing Lin* “Sterically Shielded Tetrazoles for Fluorogenic Photoclick Reaction: Tuning Cycloaddition Rate and Product Fluorescence” Org. Biomol. Chem. 2018, 16, 5241-5244.
  • Yulin Tian and Qing Lin* “Genetic Encoding of 2-Aryl-5-carboxytetrazole-Based Protein Photo-cross-linkers” Chem. Comm. 2018, 54, 4449-4452.
  • Peng An, Tracey M. Lewandowski, Tuğçe G. Erbay, Peng Liu, and Qing Lin* “Sterically shielded, stabilized nitrile imine for rapid bioorthogonal protein labeling in live cells” J. Am. Chem. Soc. 2018, 140, 4860-4868.
  • Peng An, Tracey M. Lewandowski, and Qing Lin* “Design and Synthesis of a BODIPY-Tetrazole Based “Off-On” In-Cell Fluorescent Reporter of Hydrogen Peroxide” ChemBioChem 2018, 19, 1326-1333.
  • Carlo P. Ramil, Maoqing Dong, Peng An, Tracey M. Lewandowski, Zhipeng Yu, Laurence J. Miller, and Qing Lin* “Spirohexene-Tetrazine Ligation Enables Bioorthogonal Labeling of Class B G Protein-Coupled Receptors in Live Cells” J. Am. Chem. Soc. 2017, 139, 13376-13386.
  • Alford Antoine John and Qing Lin* “Synthesis of Azobenzenes Using N-Chlorosuccinimide and 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)” J. Org. Chem. 2017, 82, 9873-9876.
  • Yulin Tian, Marco Paolo Jacinto, Yu Zeng, Zhipeng Yu, Jun Qu, Wenshe R. Liu, and Qing Lin* “Genetically encoded 2-aryl-5-carboxytetrazoles for site-selective protein photo-cross-linking” J. Am. Chem. Soc. 2017, 139, 6078-6081. Highlighted in ACS Chemical Biology Spotlight, May 19 issue, 2017.