• Damon Runyon Cancer Research Foundation Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA, 2000-2003
• PhD, Yale University, 2000
• MS, University of Pittsburgh, 1997
• BS, University of Science and Technology of China, 1994

• Co-Founder, CovalaBio Inc., 2023
• SUNY Chancellor’s Award for Excellence in Scholarship and Creative Activities, 2020
• Japan Society for the Promotion of Science (JSPS) Fellowship, 2013
• National Academies Keck Future Initiatives in Synthetic Biology Grant Award, 2010

Our research program aims to develop and apply new chemical tools and principles to solve biological problems that are difficult to solve, if not impossible, using standard biological techniques alone. A central theme of our research is to harness the power of organic reactivity to study protein dynamics, function, and assembly in living systems as well as design protein-based therapeutics. We are currently working in the following three areas:

1. Develop bioorthogonal reactions as a research tool to study protein function in various cellular systems
2. Develop new reactivity-based enabling technologies underlining covalent biologics for cancer immunotherapy
3. Design cell-penetrating domain antibodies as targeted cancer therapy

Please check our group page for details.

Google Scholar Profile Link

• Srikanth Kumar Gangam and Qing Lin* “Light-Triggered Click Chemistry” Chem. Rev. 2021, 121, 6991–7031.
• Srikanth Kumar Gangam, Stefano Racioppi, Eva Zurek, and Qing Lin* “Superfast tetrazole-BCN cycloaddition reaction for bioorthogonal protein labeling on live cells” J. Am. Chem. Soc. 2022, 144, 57–62.
• Yali Xu, Abdur Rahim and Qing Lin* “Spontaneous Orthogonal Protein Crosslinking Via a Genetically Encoded 2-Carboxy-4-Aryl-1,2,3-Triazole” Angew. Chem. Int. Ed. 2022, 61, e202202657.
• Yifang Yang, Candy Lee, Rajasekhar Reddy Reddy, David J. Huang, Weixia Zhong, Van Nguyen-Tran, Weijun Shen,* and Qing Lin* “Design of potent and proteolytically stable biaryl-crosslinked GIPR/GLP-1R peptide dual agonists” ACS Chem. Biol. 2022, 17, 1249–1258.
• Tracey M. Lewandowski, Peng An, Carlo P. Ramil, Ming Fang, and Qing Lin* “Dual fluorescent labelling of GLP-1R in live cells via enzymatic tagging and bioorthogonal chemistry” RSC Chem. Biol. 2022, 3, 702–706.
• Zheng Wang, Johnathan D. Rabb, and Qing Lin* “Orthogonal Crosslinking: A Strategy to Generate Novel Protein Topology and Function” Chem Eur J. 2023, 29, e2022028.
• Ming Fang, Gangam Srikanth Kumar, Stefano Racioppi, Heyang Zhang, Johnathan D. Rabb, Eva Zurek, and Qing Lin* “Hydrazonyl Sultones as Stable Tautomers of Highly Reactive Nitrile Imines for Fast Bioorthogonal Ligation Reaction” J. Am. Chem. Soc. 2023, 145, 9959–9964. Highlighted in C&EN News Story “Tautomerization ensures quality clicks”, May 7 issue.
• Ming Fang, Gangam Srikanth Kumar, and Qing Lin* “Systematic Structural Tuning Yields Hydrazonyl Sultones for Faster Bioorthogonal Protein Modification” ChemBioChem 2023, e20230039.
• Johnathan D. Rabb, Lucas E. Kruse, and Qing Lin* “Design of Cell-Penetrating Domain Antibodies via a Genetically Encoded β-Lactam Amino Acid” DOI: 10.26434/chemrxiv-2023-zc260.