• Fellow im Verband der Chemischen Industrie, 1989-1991
• Fellow of the Studienstiftung des Deutschen Volkes, 1982-1988
• Visiting scientist, U Auckland (NZ), 1988
• Habilitation, ETH Zürich (CH), 1998
• Dr. sc. nat ETH, ETH Zürich (CH), 1992
• Diploma Chemistry, TU Munich (D), 1988
• Prediploma Chemistry, TU Munich (D), 1985
• Prediploma Biochemistry, U Tübingen (D), 1984

• 2007 SUNY Chancellor’s Award for Excellence in Scholarship and Creative Activities
• Laukien Prize (2006)
• Scientific American 50 Award 2003 for “Chemistry and Materials”
• Buck-Whitney Medal 2003 of the ACS
• Research Innovation Award 1999, Research Corporation
• Medaille der ETH 1992

Structure determination of biological macromolecules using nuclear magnetic resonance (NMR) spectroscopy, Development of Bio-NMR techniques, Structural genomics, Metabonomics.

Our research focuses on:

• Development of Bio-NMR methodology.
• Structure determinations of biological macromolecules using nuclear magnetic resonance (NMR) spectroscopy.
• Development of NMR-based structural biology in supercooled water.
• Investigation of cellular metabolism in support of biotechnology research.
• Metabonomics

• Eletsky, A., Pulavarti, S.V., Beaumont, V., Gollnick, P., Szyperski, T. (2015) Solution NMR Experiment for Measurement of 15N-1H Residual Dipolar Couplings in Large Proteins and Supramolecular Complexes. J. Am. Chem. Soc. 137:11242-11245. PMID:26293598
• Bhardwaj, G., Mulligan, V. K., Bahl, C. D., Gilmore, J. M., Harvey, P. J., Cheneval, O., Buchko, G. W., Pulavarti, S. V., Kaas, Q., Eletsky, A., Huang, P. S., Johnson, W. A., Greisen, P. J., Rocklin, G. J., Song, Y., Linsky, T. W., Watkins, A., Rettie, S. A., Xu, X., Carter, L. P., Bonneau, R., Olson, J. M., Coutsias, E., Correnti, C. E., Szyperski, T., Craik, D. J., Baker, D. (2016) Accurate de Novo Design of Hyperstable Constrained Peptides. Nature 538: 329-335. PMID:27626386
• Jacobs, T. M., Williams, B., Williams, T., Xu, X., Eletsky, A., Federizon, J. F., Szyperski, T., Kuhlman, B. (2016) Design of Structurally Distinct Proteins Using Strategies Inspired by Evolution. Science 352: 687-690. PMID: 27151863
• Szyperski, T. (2017) Preview: Room Temperature X-Ray Crystallography Reveals Conformational Heterogeneity of Engineered Proteins. Structure 25: 691-692. PMID:28467914
• Zhang, M., Yu, X.W., Xu, Y., Jouhten, P., Swapna, G.V.T., Glaser, R.W., Hunt, J.F., Montelione, G.T., Maaheimo, H., Szyperski T. (2017) 13C Metabolic Flux Profiling of Pichia pastoris Grown in Aerobic Batch Cultures on Glucose Revealed High Relative Anabolic Use of TCA Cycle and Limited Incorporation of Provided Precursors of Branched-chain Amino Acids. FEBS J: 284: 3100-3113. PMID:28731268
• Nie, Y., Wang, S., Xu, Y, Luo, S., Zhao, Y., Xiao, R., Montelione, G.T., Hunt, J.F., Szyperski, T. (2018) Enzyme Engineering Based on X-ray Structures and Kinetic Profiling of Substrate Libraries: Alcohol Dehydrogenases For Stereospecific Synthesis of a Broad Range of Chiral Alcohols. ACS Catal.: 8, 5145-5152.
• Zhang Y, Zhong Y, Connor A.L., Miller D.P., Cao R., Shen J., Song B., Baker E.S., Tang Q., Pulavarti S.V.S.R.K., Liu R., Wang Q., Lu Z.L., Szyperski T., Zeng H., Li X., Smith R.D., Zurek E., Zhu J., Gong B. (2019) Folding and Assembly of Short a, b, g-Hybrid Peptides: Minor Variations in Sequence and Drastic Differences in Higher-Level Structures. J. Am. Chem. Soc. 141:14239-14248. PMID:31381
• Wang, X., Jing, X., Deng, Y, Nie, Y., Xu, F., Xu, Y., Zhao, Y.L., Hunt, J.F., Montelione, G.T., Szyperski, T. (2020) Evolutionary Coupling Saturation Mutagenesis: Coevolution-guided Identification of Distant Sites Influencing Bacillus Naganoensis Pullulanase Activity. FEBS Lett. 594: 799-812. PMID:31665817
• Pulavarti S.V.S.R.K, Maguire, J.B., Yuen, S., Harrison, J.S., Griffin, J., Premkumar, L., Esposito, E.A., Makhatadze, G.I., Garcia, A.E., Weiss, T.M., Snell, E.H., Kuhlman B., Szyperski T. (2022) From Protein Design to the Energy Landscape of a Cold Unfolding Protein. J Phys Chem B 126:1212-1231. PMID: 35128921
• Szyperski, T. (2022) Teaching NMR Based on the Postulates of Quantum Mechanics Makes This EASY and Relates Theory and Experiment to the Measurement Problem: The NMR Product Operator Rules. J Phys Chem A 126:8369-8371. PMID: 36801308