Szyperski, T. and Schwerdtfeger, P. (1989) On the Stability of Trioxo(η5-Cyclopentadienyl) Compounds of Manganese, Technetium and Rhenium: An ab initio SCF Study. Angew. Chem. Int. Ed. Engl.28, 1228-1231
Neri, D., Szyperski, T., Otting, G., Senn, H. and Wüthrich, K. (1989) Stereospecific Nuclear Magnetic Resonance Assignments of the Methyl Groups of Valine and Leucine in the DNA-Binding Domain of the 434 Repressor by Biosynthetically Directed Fractional 13C Labeling. Biochemistry28, 7510-7516. PMID:2692701
Szyperski, T., Neri, D., Leiting, B., Otting, G. and Wüthrich, K. (1992) Support of 1H NMR Assignments In Proteins by Biosynthetically Directed Fractional 13C-labeling. J. Biomol. NMR2, 323-334. PMID:1324756
Szyperski, T., Güntert, P., Otting, G. and Wüthrich, K. (1992) Determination of Scalar Coupling Constants by Inverse Fourier Transformation of In-Phase Multiplets. J. Magn. Reson.99, 552-560.
Szyperski, T, Güntert. P., Stone, S. R. and Wüthrich, K. (1992) Nuclear Magnetic Resonance Solution Structure of Hirudin(1-51) and Comparison with Corresponding Three-dimensional Structures Determined Using the Complete 65-Residue Hirudin Polypeptide Chain. J. Mol. Biol.228, 1193-1205. PMID:1335515
Szyperski, T., Güntert, P., Stone, S. R., Tulinsky, A., Bode, W., Huber, R. and Wüthrich, K. (1992) Impact of Protein-Protein Contacts on the Conformation of Thrombin-bound Hirudin Studied by Comparison with the Nuclear Magnetic Resonance Solution Structure of Hirudin(1-51). J. Mol. Biol.228, 1206-1211. PMID:1474586
Wüthrich, K., Szyperski, T., Leiting, B. and Otting, G. (1992) Biosynthetic Pathways of the Common Proteinogenic Amino Acids Investigated by Fractional 13C Labeling and NMR Spectroscopy. Frontiers and New Horizons in Amino Acid research, 41-48.
Szyperski, T., Wider, G., Bushweller, J. H. and Wüthrich, K. (1993) 3D 13C-15N-heteronuclear Two-spin Coherence Spectroscopy for Polypeptide Backbone Assignments in 13C-15N-double-labeled Proteins. J. Biomol. NMR3, 127-132. PMID:8448432
Szyperski, T., Luginbühl, P., Otting, G., Güntert, P. and Wüthrich, K. (1993) Protein Dynamics studied by Rotating Frame 15N Spin Relaxation Times. J. Biomol. NMR3, 151-164. PMID:7682879
Szyperski, T., Wider, G., Bushweller, J. H. and Wüthrich, K. (1993) Reduced Dimensionality in Triple-Resonance NMR Experiments. J. Am. Chem. Soc.115, 9307-9308.
Szyperski, T., Scheek, S., Johansson, J., Assmann, G., Seedorf, U. and Wüthrich, K. (1993) NMR Determination of the Secondary Structure and the Three-dimensional Polypeptide Backbone Fold of the Human Sterol Carrier Protein 2. FEBS Lett.335, 18-26. PMID: 8243660
Johansson, J., Szyperski, T., Curstedt, T. and Wüthrich, K. (1994) The NMR Structure of the Pulmonary Surfactant-Associated Polypeptide SP-C in an Apolar Solvent Contains a Valyl-Rich α-Helix. Biochemistry33, 6015-6023. PMID:8180229
Szyperski, T., Antuch, W., Schick, M., Betz, A., Stone, S. R. and Wüthrich, K. (1994) Transient Hydrogen Bonds Identified on the Surface of the NMR Solution Structure of Hirudin. Biochemistry33, 9303-9310. PMID:8049231
Ottiger, M., Szyperski, T., Luginbühl, P., Ortenzi, C., Luporini, P., Bradshaw, R. A. and Wüthrich, K. (1994) The NMR Solution Structure of the Pheromone Er-2 From the Ciliated Protozoan Euplotes raikovi. Protein Science3, 1515-1526. PMID:7833811 PMCID: PMC2142943
Szyperski, T., Pellecchia, M. and Wüthrich, K. (1994) 3D Hα/βCα/β(CO)NHN, a Projected 4D NMR Experiment for the Sequential Correlation of Polypeptide 1Hα/β,13Cα/β and Backbone 15N and 1HN Chemical Shifts. J. Magn. Reson.B105, 188-191.
Szyperski, T., Pellecchia, M., Wall, D., Georgopoulos, C. and Wüthrich, K. (1994) NMR Structure Determination of the Escherichia coli DnaJ Molecular Chaperone: Secondary Structure and Backbone Fold of the N-terminal Region (residues 2-108) Containing the Highly Conserved J Domain. Proc. Natl. Acad. Sci. USA91, 11343-11347. PMID:7972061 PMCID: PMC45227
Smith, P. E., van Schaik, R. C., Szyperski, T., Wüthrich, K. and van Gunsteren, W. F. (1995) Internal Mobility of the Basic Pancreatic Trypsin Inhibitor in Solution: A Comparison of NMR Spin Relaxation Measurements and Molecular Dynamics Simulations. J. Mol. Biol.246, 356-365. PMID: 7532721
Johansson, J., Szyperski, T. and Wüthrich, K. (1995) Pulmonary Surfactant-Associated Polypeptide SP-C in Lipid Micelles: CD Studies of Intact SP-C and NMR Secondary Structure Determination of Depalmitoyl-SP-C(1-17). FEBS Lett.362, 261-265. PMID: 7729509
Szyperski, T., Braun, D., Fernández, C., Bartels, C. and Wüthrich, K. (1995) A Novel Reduced-Dimensionality Triple-Resonance Experiment for Efficient Polypeptide Backbone Assignment, 3D CO HN N CA. J. Magn. Reson. B108, 197-203.
Szyperski, T. (1995) Biosynthetically Directed Fractional 13C-labeling of Proteinogenic Amino Acids. An Efficient Analytical Tool to Investigate Intermediary Metabolism. Eur. J. Biochem.232, 433-448. PMID: 7556192
Luginbühl, P., Szyperski, T. and Wüthrich, K. (1995) Statistical Basis for the Use of 13Cα Chemical Shifts in Protein Structure Determination. J. Magn. Reson. B109, 229-233.
Zerbe, O., Szyperski, T., Ottiger, M. and Wüthrich, K. (1996) Three-dimensional 1H-TOCSY-relayed ct-[13C,1H]-HMQC for Aromatic Spin System Identification in Uniformly 13C-labeled Proteins. J. Biomol. NMR7, 99-106. PMID: 22911006
Pellecchia, M., Szyperski, T., Wall, D., Georgopoulos, C. and Wüthrich, K. (1996) NMR Structure of the J-domain and the Gly/Phe-rich Region of the Escherichia Coli. DnaJ Chaperone. J. Mol. Biol.260, 236-250. PMID: 8764403
Szyperski, T., Braun, D., Banecki, B. and Wüthrich, K. (1996) Useful Information from Axial Peak Magnetization in Projected NMR Experiments. J. Am. Chem. Soc.118, 8146-8147.
Szyperski, T., Bailey, J. E. and Wüthrich, K. (1996) Detecting and Dissecting Metabolic Fluxes Using Biosynthetic Fractional 13C Labeling and Two-dimensional NMR Spectroscopy. Trends in Biotechnology14, 453-459.
Fernández, C., Szyperski, T., Bruyère, T., Ramage, P., Mösinger, E. and Wüthrich, K. (1997) NMR Solution Structure of the Pathogenesis-Related Protein P14a. J. Mol. Biol.266, 576-593. PMID:9067611
Pellecchia, M., Iwai, H., Szyperski, T. and Wüthrich, K. (1997) The 2D NMR Experiments H(C)CO2 and HCCO2 for Assignment and pH Titration of Carboxylate Groups in Uniformly 15N/13C-Labeled Proteins. J. Magn. Reson. 124, 274-278. PMID:9424317
Sauer, U., Hatzimanikatis, V., Bailey, J. E., Hochuli, M., Szyperski, T. and Wüthrich, K. (1997) Metabolic Fluxes in Riboflavin-producing Bacillus subtilis. Nature Biotechnol.15, 448-452. PMID: 9131624
Szyperski, T., Fernández, C. and Wüthrich, K. (1997) Two-dimensional ct-HC(C)H-COSY for Resonance Assignments of Smaller 13C-labeled Biomolecules. J. Magn. Reson. 128, 228-232. PMID:9356277
Szyperski, T., Ono, A., Fernández, C., Iwai, H., Tate, S., Wüthrich, K. and Kainosho, M. (1997) Measurement of 3JC2’P Scalar Couplings in a 17 kDa Protein Complex with 13C,15N-Labeled DNA Distinguishes the BI and BII Phosphate Conformations of the DNA. J. Am. Chem. Soc.119, 9901-9902.
Klimašauskas, S., Szyperski, T., Serva, S. and Wüthrich, K. (1998) Dynamic Modes of the Flipped-out Cytosine during HhaI Methyltransferase-DNA Interactions in Solution. EMBO J. 17, 317-324. PMID:9427765 PMCID: PMC1170382
Szyperski, T., Fernández, C., Ono, A., Kainosho, M. and Wüthrich, K. (1998) Measurement of Deoxyribose 3JHH Scalar Couplings Reveals Protein Binding-Induced Changes in the Sugar Puckers of the DNA. J. Am. Chem. Soc.120, 821-822.
Szyperski, T., Fernández, C., Mumenthaler, C. and Wüthrich, K. (1998) Structure Comparison of Human Glioma Pathogenesis-Related Protein GliPR and the Plant Pathogenesis-related Protein P14a Indicates a Functional Link between the Human Immune System and a Plant Defense System. Proc. Natl. Acad. Sci. USA95, 2262-2266. PMID: 9482873 PMCID: PMC19313
Szyperski, T., Banecki, B., Braun, D. and Glaser, R. W. (1998) Sequential Resonance Assignment of Medium-sized 15N/13C-labeled Proteins with Projected 4D Triple Resonance NMR Experiments. J. Biomol. NMR11, 387-405.
Fernández, C., Szyperski, T., Ono, A., Iwai, H., Tate, S., Kainosho, M. and Wüthrich, K. (1998) NMR with 13C,15N-doubly-labeled DNA: the Antennapedia Homeodomain Complex with a 14-mer DNA Duplex. J. Biomol. NMR12, 25-37. PMID: 9729786
Szyperski, T. (1998) 13C-NMR, MS and Metabolic flux Balancing in Biotechnology Research. Q. Rev. Biophys.31, 41-106. PMID: 9717198
Weber, F. E., Dyer, J. H., López Garcia, F., Werder, M., Szyperski, T., Wüthrich, K. and Hauser, H. (1998) In Pre-sterol Carrier Protein 2 (SCP2) in Solution the Leader Peptide 1-20 is Flexibly Disordered and the Residues 21-143 Adopt the Same Globular Fold as in Mature SCP2. Cell. Mol. Life Sci.54, 751-759. PMID: 9711242
Szyperski, T., Vandenbussche, G., Curstedt, T., Ruysschaert, J.-M., Wüthrich, K. and Johansson, J. (1998) Pulmonary Surfactant-associated Polypeptide C in a Mixed Organic Solvent Transforms From a Monomeric α-helical State Into Insoluble β-sheet Aggregates. Protein Sci.7, 2533-2540. PMID: 9865947 PMCID: PMC2143885
Pervushin, K., Ono, A., Fernández, C., Szyperski, T., Kainosho, M. and Wüthrich, K. (1998) NMR Scalar Couplings Across Watson-Crick Base Pair Hydrogen Bonds in DNA Observed by Transverse Relaxation-Optimized Spectroscopy. Proc. Natl. Acad. Sci. USA95, 14147-14151. PMID: 9826668 PMCID: PMC24341
Fiaux, J., Andersson, C. I. J., Holmberg, N., Bülow, L., Kallio, P. T., Szyperski, T., Bailey, J. E. and Wüthrich, K. (1999) 13C NMR Flux Ratio Analysis of Escherichia coli Central Carbon Metabolism in Microaerobic Bioprocesses. J. Am. Chem. Soc.121, 1407-1408.
Szyperski, T., Götte, M., Billeter, M., Perola, E., Cellai, L., Heumann, H. and Wüthrich, K. (1999). NMR Structure of the Chimeric Hybrid Duplex r(gcaguggc)·r(gcca)d(CTGC) Comprising the tRNA-DNA Junction Formed During Initiation of HIV-1 Reverse Transcription. J. Biomol. NMR13, 343-355. PMID: 10353196
Szyperski, T., Glaser, R. W., Hochuli, M., Fiaux, J., Sauer, U., Bailey, J. E. and Wüthrich, K. (1999) Bioreaction Network Topology and Metabolic Flux Ratio Analysis by Biosynthetic Fractional 13C Labeling and Two-dimensional NMR Spectroscopy. Metabolic. Eng.1, 189-197. PMID:10937933
Hochuli, M., Patzelt, H., Oesterhelt, D., Wüthrich, K. and Szyperski, T. (1999) Amino Acid Biosynthesis in the Halophilic Archaeon Haloarcula hispanica. J. Bacteriol.181, 3226-3237. PMID:10322026 PMCID: PMC93780
Szyperski, T., Fernández, C., Ono, A., Wüthrich, K. and Kainosho, M. (1999) The 2D {31P} Spin-echo-difference Constant-time [13C, 1H]-HMQC Experiment for Simultaneous Determination of 3JH3’P and 3JC4’P in 13C-Labeled Nucleic Acids and Their Protein Complexes. J. Magn. Reson.140, 491-494. PMID:10497056
Fernández, C., Szyperski, T., Billeter, M., Ono, A., Iwai, H., Kainosho, M. and Wüthrich, K. (1999) Conformational Changes of the BS2 Operator DNA Upon Complex Formation with the Antennapedia Homeodomain Studied by NMR with 13C/15N-labeled DNA. J. Mol. Biol. 292, 609-617. PMID:10497025
Sauer, U., Lasko, D. R., Fiaux, J., Hochuli, M., Glaser, R., Szyperski, T., Wüthrich, K. and Bailey, J. E. (1999) Metabolic Flux Ratio (METAFoR) Analysis of Genetic and Environmental Modulations of Escherichia coli Central Carbon Metabolism. J. Bacteriol.181, 6679-6688. PMID:10542169 PMCID: PMC94132
Lopez Garcia, F., Szyperski, T., Dyer, J. H., Choinowski, T., Seedorf, U., Hauser, H. and Wüthrich, K. (2000) NMR Structure of the Sterol Carrier Protein-2: Implications for the Biological Role. J. Mol. Biol. 295, 595-603. PMID:10623549
Sauer, U., Szyperski, T and Bailey, J. E. (2000) Future Trends in Complex Microbial Reaction Studies. In: Barbotin, J.-N., Portais, J.-C. editors. NMR in Microbiology: Theory and Application. Norfolk (UK): Horizon Scientific Press. 479-490.
Skalicky, J. and Szyperski, T (2000) Two-Dimensional NMR Spectroscopy. In: Barbotin, J.-N., Portais, J.-C. editors. NMR in Microbiology: Theory and Application. Norfolk (UK): Horizon Scientific Press. 157-166.
Hochuli, M., Szyperski, T. and Wüthrich, K. (2000) Deuterium Isotope Effects on the Central Carbon Metabolism of Escherichia coli Cells Grown on a D2O-containing Minimal Medium. J. Biomol. NMR17, 33-42. PMID:10909864
Skalicky, J. J., Sukumaran, D. K., Mills, J. L. and Szyperski, T. (2000) Toward Structural Biology in Supercooled Water. J. Am. Chem. Soc.122, 3230-3231.
Montelione, G. T., Zheng, D., Huang, Y., Gunsalus, K. C. and Szyperski, T. (2000) Protein NMR Spectroscopy in Structural Genomics. Nature Struc. Biol. 7, 982-985. PMID: 11104006
Frey, A. D., Fiaux, J., Szyperski, T., Wüthrich, K., Bailey, J. E., and Kallio, P. T. (2001) Dissection of Central Carbon Metabolism of Hemoglobin-Expressing Escherichia coli by 13C Nuclear Magnetic Resonance Flux Distribution Analysis in Microaerobic Bioprocesses. Appl. Environ. Microbiol. 67, 680-687. PMID: 11157231 PMCID: PMC92635
Skalicky, J. J., Mills, J. L., Sharma, S. and Szyperski, T. (2001) Aromatic Ring-flipping in Supercooled Water: Implications for NMR-based Structural Biology of Proteins. J. Am. Chem. Soc.123, 388-397. PMID:11456540
Canonaco, F., Hess, T. A., Heri, S., Wang, T., Szyperski, T. and Sauer, U. (2001) Metabolic Flux Response to Phosphoglucose Isomerase Knock-out in Escherichia Coli and Impact of Overexpression of the Soluble Transhydrogenase UdhA. FEMS Microbiol. Lett. 204, 247-252. PMID:11731130
Maaheimo, H., Fiaux, J., Cakar, Z. P., Bailey, J. E., Sauer, U. and Szyperski, T. (2001) Central Carbon Metabolism of Saccharomyces cerevisiae Explored by Biosynthetic Fractional 13C Labeling of Common Amino Acids. Eur. J. Biochem.268, 2464-2479. PMID:11298766
Emmerling, M., Dauner, M., Ponti, A., Fiaux, J., Hochuli, M., Szyperski, T., Wüthrich, K., Bailey, J. E. and Sauer, U. (2001) Metabolic Flux Response to Pyruvate Kinase Knockout in Escherichia Coli. J. Bacteriol.184, 152-164. PMID:11741855 PMCID: PMC134756
Dauner, M., Sonderegger, M., Hochuli, M., Szyperski, T., Wüthrich, K., Hohmann, H. P., Sauer, U. (2002) Intracellular Carbon Fluxes in Riboflavin-Producing Bacillus subtilis during Growth on Two-Carbon Substrate Mixtures. Appl. Environ. Microbiol.68, 1760-1771. PMID:11916694 PMCID: PMC123836
Monleón, D., Colson, K., Moseley, H. N. B., Anklin, C., Oswald, R., Szyperski, T. and Montelione, G. T. (2002) Rapid Analysis of Protein Backbone Resonance Assignments using Cryogenic Probes, a Distributed Linux-based Computing Architecture, and an Integrated Set of Spectral Analysis Tools. J. Struc. Func. Genomics2, 93-101. PMID: 12836666
Szyperski, T., Yeh, D. C., Sukumaran, D. K., Moseley, H. N. B. and Montelione, G. T. (2002) Reduced-dimensionality NMR Spectroscopy for High-Throughput Protein Resonance Assignment. Proc. Natl. Acad. Sci. USA99, 8009-8014. PMID:12060747 PMCID: PMC123011
Szymczyna, B. R., Pineda-Lucena, A., Mills, J. L., Szyperski, T. and Arrowsmith, C. (2002) 1H, 13C and 15N Resonance Assignments and Secondary Structure of the PWI Domain from SRm160 using Reduced Dimensionality NMR. J. Biomol. NMR22, 299-300. PMID: 11991360
Mills, J. L. and Szyperski, T. (2002) Protein Dynamics in Supercooled Water: The Search for Slow Motional Modes. J. Biomol. NMR23, 63-67. PMID:12061719
Szyperski, T. (2002) Strukturelle Genomik. Nachrichten aus der Chemie50, 1128-1131.
Xia, Y., Arrowsmith, C. H. and Szyperski, T. (2002) Novel Projected 4D Triple Resonance Experiments for Polypeptide Backbone Chemical Shift Assignment. J. Biomol. NMR24, 41-50. PMID:12449417
Gong, B., Zeng, H., Zhu, J., Yua, L., Han, Y., Cheng, S., Furukawa, M., Parra, R. D., Kovalevsky, A. Y., Mills, J. L., Skrzypczak-Jankun, E., Martinovic, S., Smith, R. D., Zheng, C., Szyperski, T. and Zeng, X. C. (2002) Creating Nanocavities of Tunable Sizes: Hollow Helices. Proc. Natl. Acad. Sci. USA99, 11583-11588. PMID:12177422 PMCID: PMC129312
Fiaux, J., Cakar, Z. P., Sonderegger, M., Wüthrich, K., Szyperski, T. and Sauer, U. (2003) Metabolic-Flux Profiling of the Yeasts Saccharomyces cerevisiae and Pichia stipitis. Eukaryotic Cell2, 170-180. PMID:12582134 PMCID: PMC141173
Kim, S. and Szyperski, T. (2003) GFT NMR, a New Approach to Rapidly Obtain Precise High-Dimensional NMR Spectral Information. J. Am. Chem. Soc.125, 1385-1393. PMID: 12553842
Daujotytė, D., Vilkaitis, G., Manelytė, L., Skalicky, J., Szyperski, T. and Klimašauskas, S. (2003) Solubility Engineering of the HhaI Methyltransferase. Protein Eng.16, 295-301. PMID:12736373
Liu, G., Mills, J. L., Hess, T. A., Kim, S., Skalicky, J. J., Sukumaran, D. K., Kupce, E., Skerra, A., Szyperski, T. (2003) Resonance Assignments for the 21 kDa Engineered Fluorescein-binding Lipocalin FluA. J. Biomol. NMR27, 187-188. PMID: 12913418
Aramini, J. M., Mills, J. L., Xiao, R., Acton, T. B., Wu, M. J., Szyperski, T. and Montelione, G. T. (2003) Letter to the Editor: Resonance Assignments for the Hypothetical Protein yggU from Escherichia coli. J. Biomol. NMR27, 285-286. PMID:12975589
Monleón, D., Chiang, Y., Aramini, J. M., Swapna, G. V. T., Macapagal, D., Gunsalus, K. C., Kim, S., Szyperski, T. and Montelione, G. T. (2004) Letter to the Editor: Backbone 1H, 15N and 13C Assignments for the 21 kDa Caenorhabditis elegans Homologue of ‘Brain-Specific’ Protein. J. Biomol. NMR28, 91-92. PMID: 14739645
Kim, S. and Szyperski, T. (2004) GFT NMR Experiments for Polypeptide Backbone and 13Cβ Chemical Shift Assignment. J. Biomol. NMR28, 117-130. PMID:14755156
Xu, D., Liu, G., Xiao, R., Acton, T., Goldsmith-Fischman, S., Honig, B., Montelione, G. T. and Szyperski, T. (2004) NMR Structure of the Hypothetical Protein AQ-1857 Encoded by the Y157 Gene from Aquifex aeolicus Reveals a Novel Protein Fold. Proteins54, 794-796. PMID:14997575
Liu, G., Sukumaran, D. K., Xu, D., Chiang, Y., Acton, T., Goldsmith-Fischman, S., Honig, B., Montelione, G. T. and Szyperski, T. (2004) NMR Structure of the Hypothetical Protein NMA1147 from Neisseria meningitidis Reveals a Distinct 5-Helix Bundle. Proteins55, 756-758. PMID:15103637
Herve du Penhoat, C., Atreya, H. S., Shen, Y., Liu, G., Acton, T. B., Xiao, R., Li, Z., Murray, D., Montelione, G. T. and Szyperski, T. (2004) The NMR Solution Structure of the 30S Ribosomal Protein S27e Encoded in Gene RS27_ARCFU of Archaeoglobus fulgidis Reveals a Novel Protein Fold. Protein Sci.13, 1407-1416. PMID: 15096641 PMCID: PMC2286747
Solà, A., Maaheimo, H., Ylönen, K., Ferrer, P. and Szyperski, T. (2004) Amino Acid Biosynthesis and Metabolic Flux Profiling of Pichia pastoris. Eur. J. Biochem. 271, 2462-2470. PMID:15182362
Zamboni, N., Maaheimo, H., Szyperski, T., Hohmann, H.-P., and Sauer, U. (2004) The Phosphoenolpyruvate Carboxykinase also Catalyzes C3 Carboxylation at the Interface of Glycolysis and the TCA Cycle of Bacillus subtilis. Metabolic Eng. 6, 277-284. PMID: 15491857
Shen, Y., Atreya, H. S., Xiao, R., Acton, T. B., Shastry, R., Ma, L., Montelione, G. T. and Szyperski, T. (2004) Letter to the Editor: Resonance Assignments for the 18 kDa Protein CC1736 from Caulobacter crescentus. J. Biomol. NMR29, 549-550. PMID:15243193
Moseley, H. N. B., Riaz, N., Aramini, J. M., Szyperski, T. and Montelione, G. T. (2004) A Generalized Approach to Automated NMR Peak List Editing: Application to Reduced Dimensionality Triple Resonance Spectra. J. Magn. Reson.170, 263-277. PMID:15388090
Atreya, H. S. and Szyperski, T (2004) G-matrix Fourier Transform NMR Spectroscopy for Complete Protein Resonance Assignment. Proc. Natl. Acad. Sci. USA101, 9642-9647. PMID:15210958 PMCID: PMC470728
Yuan, L., Zeng, H., Yamato, K., Sanford, A. R., Feng, W., Atreya, H. S., Sukumaran, D. K., Szyperski, T. and Gong, B. (2004) Helical Aromatic Oligoamides: Reliable, Readily Predictable Folding from the Combination of Rigidified Structural Motifs. J. Am. Chem. Soc.126, 16528-16537. PMID:15600357
Atreya, H. S. and Szyperski, T. (2005) Rapid NMR Data Collection. Methods Enzymol.394, 78-108. PMID:15808218
Huang, Y. J., Moseley, H., Baran, M. C., Arrowsmith, C., Powers, R., Tejero, R., Szyperski, T. and Montelione, G. T. (2005) An Integrated Platform for Automated Analysis of Protein NMR Structures. Methods Enzymol.394, 111-140. PMID:15808219
Shen, Y., Goldsmith-Fischman, S., Atreya, H. S., Acton, T., Ma, L., Xiao, R., Honig, B., Montelione, G. T. and Szyperski, T. (2005) NMR Structure of the 18 kDa Protein CC1736 From Caulobacter crescentus Identifies a Member of the “START” Domain Superfamily and Suggests Residues Mediating Substrate Specificity. Proteins58, 747-750. PMID: 15616961
Liu, G., Li, Z., Chiang, Y., Acton, T., Montelione, G. T., Murray, D. and Szyperski, T. (2005) High-quality Homology Models Derived from NMR and X-ray Structures of E. coli Proteins Y gdK and Suf E Suggest that All Members of the Y gdK/Suf E Protein Family are Enhancers of Cysteine Desulfurases. Protein Sci.14, 1597-1608. PMID: 15930006 PMCID: PMC2253389
Hervé du Penhoat, C., Li, Z., Atreya, H. S., Kim, S., Yee, A., Xiao, R., Murray, D., Arrowsmith, C. H. and Szyperski, T. (2005) NMR Solution Structure of Thermotoga maritima Protein TM1509 Reveals a Zn-metalloprotease-like Tertiary Structure. J. Struc. Func. Genomics6, 51-62. PMID:15965736
Szyperski, T. (2005). Protein NMR Spectroscopy. In: Meyers, R.A., editor. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Wiley-CH, Weinheim.
Atreya, H. S., Eletsky, A. and Szyperski, T. (2005) Resonance Assignment of Proteins with High Shift Degeneracy Based on 5D Spectral Information Encoded in G2FT NMR Experiments. J. Am. Chem. Soc.127, 4554-4555. PMID:15796503
Shen, Y., Atreya, H. S., Liu, G. and Szyperski, T. (2005) G-matrix Fourier Transform NOESY-Based Protocol for High-Quality Protein Structure Determination. J. Am. Chem. Soc.127, 9085-9099. PMID: 15969587
Liu, G., Aramini, J., Atreya, H. S., Eletsky, A., Xiao, R., Acton, T., Ma, L. C., Montelione, G. T. and Szyperski, T. (2005) GFT NMR Based Resonance Assignment for the 21 kDa Human Protein UFC1. J. Biomol. NMR32, 261. PMID:16132835
Pineda-Lucena, A., Ho, C. S. W., Mao, D. Y. L., Sheng, Y., Laister, R. C., Muhandiram, R., Lu, Y., Seet, B. T., Katz, S., Szyperski, T., Penn, L. Z. and Arrowsmith, C. H. (2005) A Structure-based Model of the c-Myc/Bin1 Protein Interaction Shows Alternative Splicing of Bin1 and c-Myc Phosphorylation are Key Binding Determinants. J. Mol. Biol.351, 182-194. PMID:15992821
Liu, G., Shen, Y., Atreya, H. S., Parish, D., Shao, Y., Sukumaran, D., Xiao, R., Yee, A, Lemak, A., Bhattacharya, A., Acton, T. A., Arrowsmith, C. H., Montelione, G. T. and Szyperski, T. (2005) NMR Data Collection and Analysis Protocol for High-throughput Protein Structure Determination. Proc. Natl. Acad. Sci. USA102, 10487-10492. PMID: 16027363 PMCID: PMC1180791
Eletsky, A., Atreya, H. S., Liu, G. and Szyperski, T. (2005) Probing Structure and Functional Dynamics of (Large) Proteins with Aromatic Rings: L-GFT-TROSY (4,3)D HCCH NMR Spectroscopy. J. Am. Chem. Soc.127, 14578-14579. PMID:16231903
Szyperski, T., Mills, J. L., Perl, D. and Balbach, J. (2006) Combined NMR-observation of Cold Denaturation in Supercooled Water and Heat Denaturation Enables Accurate Measurement of ΔCp of Protein Unfolding. Eur. Biophys. J.35, 363-366. PMID:16240113
Szyperski, T. (2006) Principles and Application of Projected Multidimensional NMR Spectroscopy – G-matrix Fourier Transform NMR. Springer Series in Biophysics10, (Advanced Techniques in Biophysics), 147-162.
Liu, G., Shen, Y., Xiao, R., Acton, T., Ma, L. C., Joachimiak, A., Montelione, G. T. and Szyperski, T. (2006) NMR Structure of Protein yqbG from Bacillus subtilis Reveals a Novel α-Helical Protein Fold. Proteins62, 288-291. PMID:16281282
Szyperski, T. and Atreya, H. S. (2006) Principles and Applications of GFT Projection NMR Spectroscopy. Magn. Reson. Chem.44, S51-S60. PMID:16826541
Mukherjee, S., Muralidhar, D., Atreya, H. S., Szyperski, T., Jeromin, A., Sharma, Y. and Chary, K. V. R. (2006) 1H, 13C and 15N Chemical Shift Assignments for Neuronal Calcium Sensor-1, a Multi-functional Calcium-binding Protein. J. Biomol. NMR, 36, Suppl 1:48. PMID:16804767
Lin, Y-C., Liu, G., Shen, Y., Bertonati, C., Yee, A., Honig, B., Arrowsmith, C. H., and Szyperski, T. (2007) NMR Structure of Protein PA2021 from Pseudomonas aeruginosa. Proteins65, 767-770. PMID:16927296
Solà, A., Jouhten, P., Maaheimo, H., Sànchez-Ferrando, F. and Szyperski, T., Ferrer, P. (2007) Metabolic Flux Profiling of Pichia pastoris Grown on Glycerol/methanol Mixtures in Chemostat Cultures at Low and High Dilution Rates. Microbiology153, 281-290. PMID: 17185557
Singarapu, K. K., Liu, G., Xiao, R., Bertonati, C., Honig, B., Montelione, G. T. and Szyperski, T. (2007) NMR Structure of Protein yjbR from Escherichia coli Reveals 'Double-wing' DNA Binding Motif. Proteins67, 501-504. PMID:17266124
Atreya, H. S., Garcia, E., Shen, Y. and Szyperski, T. (2007). J-GFT NMR for Precise Measurement of Mutually Correlated Nuclear Spin-Spin Couplings. J. Am. Chem. Soc. 129, 680-692. PMID:17227032
Szyperski, T. (2007). Protein NMR Spectroscopy. In: Meyers, R.A., editor. Proteins. From Analytics to Structural Genomics. Wiley-CH, Weinheim.
Singarapu, K. K., Xiao, R., Sukumaran, D. K., Acton, T., Montelione, G. T. and Szyperski, T. (2008) NMR structure of protein Cgl2762 from Corynebacterium glutamicum implicated in DNA transposition reveals a helix-turn-helix motif attached to a flexibly disordered leucine zipper. Proteins70, 1650-1654. PMID:18175328
Shen, Y. and Szyperski, T. (2008) Structure of the Protein BPTI Derived with the NOESY in Supercooled water: Validation and Refinement of Solution Structures. Angew. Chem. Int. Ed. Engl.47, 324-326. PMID:17994654
Singarapu, K. K., Xiao, R., Acton, T., Rost, B., Montelione, G. T. and Szyperski, T. (2008) NMR Structure of the Peptidyl-tRNA Hydrolase Domain from Pseudomonas syringae Expands the Structural Coverage of the Hydrolysis Domains of Class 1 Peptide Chain Release Factors. Proteins71, 1027-1031. PMID:18247350
Li, M., Yamato, K., Ferguson, J. S., Singarapu, K. K., Szyperski, T. and Gong, B. (2008) Sequence-specific, Dynamic Covalent Crosslinking in Aqueous Media. J. Am. Chem. Soc.130, 491-500. PMID:18092773
Zhang, Q., Atreya, H. S., Kamen, D. E., Girvin, M. E. and Szyperski, T. (2008) GFT Projection NMR Based Resonance Assignment of Membrane Proteins: Application to Subunit of E. coli F(1)F(0) ATP Synthase in LPPG Micelles. J. Biomol. NMR40, 157-163. PMID:18273680
Shen, Y., Lange, O., Delaglio, F., Rossi, P., Aramini, J. M., Liu, G., Eletsky, A., Wu, Y., Singarapu, K. K., Lemak, A., Ignatchenko, A., Arrowsmith, C. H., Szyperski, T., Montelione, G. T., Baker, D. and Bax, A. (2008) Consistent Blind Protein Structure Generation from NMR Chemical Shift Data. Proc. Natl. Acad. Sci. USA105, 4685-4690. PMID:18326625 PMCID: PMC2290745
Parish, D. M. and Szyperski, T. (2008) Simultaneously Cycled NMR Spectroscopy. J. Am. Chem. Soc.130, 4925-4933. PMID:18338896
Szyperski, T. (2008) On NMR-based Structural Proteomics. In: Structural Proteomics (Eds. J.L. Sussman and I. Silman), World Scientific Publishing, New York.
Snyder, D. A., Ghosh, A., Zhang, F., Szyperski, T. and Bruschweiler, R. (2008) Z-matrix Formalism for Quantitative Noise Assessment of Covariance Nuclear Magnetic Resonance Spectra. J. Chem. Phys.129, 104511. PMID:19044928 PMCID: PMC2669766
Parish, D., Benach, J., Liu, G., Singarapu, K. K., Xiao, R., Acton, T., Su, M., Bansal, S., Prestegard, J. H., Hunt, J., Montelione, G. T. and *Szyperski, T. (2008) Protein Chaperones Q8ZP25_SALTY from Salmonella typhimurium and HYAE_ECOLI from Escherichia coli exhibit Thioredoxin-like Structures Despite Lack of Canonical Thioredoxin Active Site Sequence motive. J. Struc. Funct. Genomics9, 41-49. PMID:19039680 PMCID: PMC2850599 NIHMS180356
Liu, G., Forouhar, F., Eletsky, A., Atreya, H. S., Aramini, J. M., Xiao, R., Huang, Y. J., Abashidze, M., Seetharaman, J., Liu, J., Rost, B., Acton, T., Montelione, G. T., Hunt, J. F. and Szyperski, T. (2009) NMR and X-RAY Structures of Human E2-like Ubiquitin-fold Modifier Conjugating Enzyme 1 (UFC1) Reveal Structural and Functional Conservation in the Metazoan UFM1-UBA5-UFC1 Ubiquination Pathway. J. Struc. Funct. Genomics 10:127-136. PMID:19101823 PMCID: PMC2850604 NIHMS180335
Wu, Y., Ghosh, A. and Szyperski, T. (2009) Clean Absorption-Mode NMR Data Acquisition. Angew. Chem. Int. Ed. Engl.48, 1479-1483. PMID:19140147 PMCID: PMC3018340 NIHMS148775
Montelione, G. T., Arrowsmith, C. H., Girvin, M. E., Kennedy, M. A., Markley, J. L., Powers, R., Prestegard, J. H. and Szyperski, T. (2009) Unique Opportunities for NMR Methods in Structural Genomics. J. Struc. Funct. Genomics10, 101-106. PMID: 19288278 PMCID: PMC2705713
Yamamoto, S., Eletsky, A., Szyperski, T., Hay, J. and Ruyechan, W. T. (2009) Analysis of the Varicella-zoster Virus IE62 N-terminal Acidic Transactivating Domain and its Interaction with the Human Mediator Complex. J. Virol.83, 6300-6305. PMID: 19357160 PMCID: PMC2687382
Eletsky, A., Sukumaran, D. K., Xiao, R., Acton, T. B., Rost, B., Montelione, G. T. and Szyperski, T. (2009) NMR Structure of Protein YvyC from Bacillus subtilis Reveals Unexpected Structural Similarity Between Two PFAM families. Proteins76, 1037-1041. PMID: 19455708 PMCID: PMC2735722 NIHMS130534
Wu, Y., Ghosh, A. and Szyperski, T. (2009) Clean Absorption Mode NMR Data Acquisition Based on Time-Proportional Phase Incrementation. J. Struc. Funct. Genomics10, 227-232. PMID: 19499349 PMCID: PMC2850597 NIHMS180353
Mills, J. L., Liu, G., Skerra, A. and Szyperski, T. (2009) NMR Structure and Dynamics of the Engineered Fluorescein-binding Lipocalin FluA Reveal Rigidification of Beta-barrel and Variable Loops Upon Enthalpy-driven Ligand Binding. Biochemistry11, 7411-7419. PMID: 19603796 PMCID: PMC2860743 NIHMS132867
Sukumaran, D. K., Garcia, E., Hua, J., Tabaczynski, W., Odunsi, K., Andrews, C. and *Szyperski, T. (2009) Standard Operating Procedure For Metabonomics Studies of Blood Serum and Plasma Samples Using a 1H-NMR Micro-flow Probe. Magn. Reson. Chem.47: S81-S85. PMID: 19688872
Das, R., Andre, I., Shen, Y., Wu, Y., Lemak, A., Bansal, S., Arrowsmith, C. H., Szyperski, T. and Baker, D. (2009) Simultaneous Prediction of Protein Folding and Docking at High Resolution. Proc. Natl. Acad. Sci. USA106, 18978-18983. PMID: 19864631 PMCID: PMC2770007
Singarapu, K. K., Mills, J. L., Xiao, R., Acton, T., Punta, M., Fischer, M., Honig, B., Rost, B., Montelione, G. T. and Szyperski, T. (2010) Solution NMR structures of Proteins VPA0419 from Vibrio parahaemolyticus and yiiS from Shigella flexneri Provide Structural Coverage for Protein Domain Family PFAM 04175. Proteins78, 779-784. PMID: 19927321 PMCID: PMC2860719 NIHMS156040
Raman, S., Lange, O. F., Rossi, P., Tyka, M., Wang, X., Aramini, J., Liu, G., Ramelot, T. A., Eletsky, A., Szyperski, T, Kennedy, M. A., Prestegard, J., Montelione, G. T. and Baker, D. (2010) NMR Structure Determination for Larger Proteins using Backbone-only Data. Science327:1014-1018. PMID: 20133520 PMCID: PMC2909653 NIHMS211856
Montelione, G.T. and Szyperski, T. (2010) Advances in Protein NMR Provided by the NIGMS Protein Structure Initiative: Impact on Drug Discovery. Curr. Opin. Drug Discov. 13, 335-349. PMID: 20443167
Love, J., Mancia, F., Shapiro, L., Punta, M., Rost, B., Girvin, M., Wang, D. N., Zhou, M., Hunt, J. F., Szyperski, T., Gouaux, E., MacKinnon, R., McDermott, A., Honig, B., Inouye, M., Montelione, G. T., and Hendrickson, W. A. (2010) The New York Consortium on Membrane Protein Structure Determination: a High-throughput Platform for Structural Genomics of Integral Membrane Proteins. J. Struct. Funct. Genomics11, 191-199. PMID: 20690043 PMCID: PMC3099345 NIHMS233280
Jha R.K., Leaver-Fay, A., Yin, S., Wu, Y., Butterfoss, G.L., Szyperski, T., Dokholyan, N.V., and Kuhlman, B. (2010) Computational Design of a PAK1 Binding Protein. J. Mol. Biol.400, 257-270. PMID: 20460129 PMCID: PMC2903434 NIHMS212557
Franks, W. T., Atreya, H. S., Szyperski, T. and Rienstra, C. M. (2010) GFT Projection NMR Spectroscopy for Proteins in the Solid State. J. Biomol. NMR48, 213-223. PMID: 21052779 PMCID: PMC3058792 NIHMS265136
Garcia, E., Andrews, C., Hua, J., Kim, H. L., Sukumaran, D. K., Szyperski, T. and Odunsi, K. (2011) Diagnosis of Early Stage Ovarian Cancer by 1H NMR Metabonomics of Serum Explored by Use of a Microflow NMR Probe. J. Proteome Res.10: 1765-1771. PMID: 21218854 PMCID: PMC3074977 NIHMS275348
Szyperski, T. and Montelione, G. T. (2011) Advances in NMR-based Structural Genomics. In: Biomolecular NMR Spectroscopy (Eds. A.J. Dingley and S.M. Pascal), IOS Press, Amsterdam.
Eletsky, A., Ruyechan, W. T., Xiao, R., Acton, T. B., Montelione, G. T. and Szyperski, T. (2011) Solution NMR structure of MED25(391-543) Comprising the Activator-interacting Domain (ACID) of Human Mediator Subunit 25. J. Struct. Funct. Genomics12:159-166. PMID: 21785987 PMCID: PMC3609412 NIHMS405907
Szyperski, T. and Mills, J. L. (2011) NMR-based Structural Biology in Supercooled Water. J. Struct. Funct. Genomics12:1-7. PMID: 21533787
Ghosh, A., Wu, Y., He, Y. and Szyperski, T. (2011) Theory of Mirrored Time Domain sampling. J. Magn. Reson.213:46-57. PMID: 21974999
Der, B. S., Machius, M., Miley, M. J., Mills, J. L., Szyperski, T. and Kuhlman, B. (2012) Metal-Mediated Affinity and Orientation Specificity in a Computationally Designed Protein Homodimer. J. Am. Chem. Soc.134:375-85. PMID:22092237 PMCID: PMC3257401 NIHMS344730
Eletsky, A., Acton, T. B., Xiao, R., Everett, J. K., Montelione, G. T. and Szyperski, T. (2012) Solution NMR Structures Reveal a Distinct Architecture and Provide First Structures for Protein Domain Family PF04536. J. Struct. Funct. Genomics13:9-14. PMID:22198206 PMCID: PMC3609422 NIHMS405906
Eletsky, A., Petrey, D., Zhang, Q. C., Lee, H. W., Acton, T. B., Xiao, R., Everett, J. K., Prestegard, J. H., Honig, B., Montelione, G. T. and Szyperski, T. (2012) Solution NMR Structures Reveal Unique Homodimer Formation by a Winged Helix-turn-helix Motif and Provide First Structures for Protein Domain Family PF10771. J. Struct. Funct. Genomics13:1-7. PMID: 22223187 NIHMS405905
Rosato A., Aramini, J. M., Arrowsmith C., Bagaria A., Baker D., Cavalli A., Doreleijers, J. F., Eletsky, A., Giachetti, A., Guerry, P., Gutmanas, A., Güntert, P., He, Y., Herrmann, T., Huang, Y.J., Jaravine, V., Jonker, H. R., Kennedy, M. A., Lange, O. F., Liu, G., Malliavin, T. E., Mani, R., Mao, B., Montelione, G. T., Nilges, M., Rossi, P., van der Schot, G., Schwalbe, H., Szyperski, T. A., Vendruscolo, M., Vernon, R., Vranken ,W. F., Vries, S.d., Vuister, G. W., Wu, B., Yang, Y., Bonvin, A. M. (2012) Blind Testing of Routine, Fully Automated Determination of Protein Structures from NMR Data. Structure20:227-236. PMID: 22325772 PMCID: PMC3609704 NIHMS353547
Murphy, G. S., Mills, J. L., Miley, M. J., Machius, M., Szyperski, T. and Kuhlman, B. (2012) Increasing Sequence Diversity with Flexible Backbone Protein Design: the Complete Redesign of a Protein Hydrophobic core. Structure20:1086-1096. PMID: 22632833 PMCID: PMC3372604 NIHMS374182
Thompson, J. M., Sgourakis, N. G., Liu, G., Rossi, P., Tang, Y., Mills, J. L., Szyperski, T., Montelione, G. T. and Baker, D. (2012) Accurate Protein Structure Modeling using Sparse NMR Data and Homologous Structure Information. Proc. Natl. Acad. Sci. USA109:9875-9880. PMID:22665781 PMCID: PMC3382498
Wu, Y., Punta, M., Xiao, R., Acton, T. B., Sathyamoorthy, B., Dey, F., Fischer, M., Skerra, A., Rost, B., Montelione, G. T. and Szyperski T. (2012) NMR Structure of Lipoprotein YxeF from Bacillus subtilis Reveals a Calycin Fold and Distant Homology with the Lipocalin Blc from Escherichia coli. PLoS One7:e37404. PMID:22693626 PMCID: PMC3367933
Eletsky, A., Jeong, M.Y., Kim, H., Lee, H.W., Xiao, R., Pagliarini, D.J., Prestegard, J.H., Winge, D.R., Montelione, G.T., Szyperski, T. (2012) Solution NMR Structure of Yeast Succinate Dehydrogenase Flavinylation Factor Sdh5 Reveals a Putative Sdh1 Binding Site. Biochemistry51:8475-8477. PMID:23062074
Reig, A.J., Pires, M.M., Snyder, R.A., Wu, Y., Jo, H., Kulp, D.W., Butch, S.E., Calhoun, J.R., Szyperski, T., Solomon, E.L., DeGrado, W.F. (2012) Alteration of the Oxygen-Dependent Reactivity of de novo Due Ferri Proteins. Nat. Chem.4:900-906. PMID:23089864 PMCID: PMC3568993 NIHMS399993
Rinaudo, P., Shen, S., Hua, J., Qian, S., Prabhu, U., Garcia, E., Cedars, M., Sukumaran, D., *Szyperski, T., Andrews, C. (2012) (1)H NMR Based Profiling of Spent Culture Media Cannot Predict Success of Implantation for Day 3 Human Embryos. J. Assist. Reprod. Genet.29:1435-1442. PMID:23090745 PMCID: PMC3528870
Atreya, H.S., Sathyamoorthy, B., Jaipuria, G., Beaumont, V., Varani, G., *Szyperski, T. (2012) GFT Projection NMR for Efficient (1)H/(13)C Sugar Spin System Identification in Nucleic Acids. J. Biomol. NMR54:337-342. PMID:23192291 [PubMed in progress]
Manning, K.A., Sathyamoorthy, B., Eletsky, A., Szyperski, T., Murkin, A.S. (2012) Highly Precise Measurement of Kinetic Isotope Effects Using 1H-Detected 2D [13C,1H]-HSQC NMR Spectroscopy. J. Am. Chem. Soc.134:20589-20592. PMID:23215000
Mills, J.L., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., *Szyperski, T. (2013) Solution NMR structure of the Helicase Associated Domain BVU_0683(627-691) from Bacteroides vulgatus Provides First Structural Coverage for Protein Domain Family PF03457 and Indicates Domain Binding to DNA. J Struct. Funct. Genomics14: 19-24. PMID:23160728 NIHMS423432
Sathyamoorthy, B., Singarapu, K.K., Garcia, A.E., *Szyperski, T. (2013) Protein Conformational Space Populated in Solution Probed with Aromatic Residual Dipolar (13)C-(1)H Couplings. ChemBioChem14:684-688. PMID:23494854
Pulavarti, S.V., He, Y., Feldmann, E.A., Eletsky, A., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Kennedy, M.A., Szyperski, T. (2013) Solution NMR Structures Provide First Structural Coverage of the Large Protein Domain Family PF08369 and Complementary Structural Coverage of Dark Protochlorophyllide Oxidoreductase Complexes. J. Struct. Funct. Genomics14: 119-126. PMID: 23963952
Pulavarti, S.V., Eletsky, A., Lee, H.W., Acton, T.B., Xiao, R., Everett, J.K., Prestegard, J.H., Montelione, G.T., Szyperski, T. (2013) Solution NMR structure of CD1104D from Pathogenic Clostridium Difficile Reveals a Distinct a-Helical Architecture and Provides First Structural Representative of Protein Domain Family PF14203. J. Struct. Funct. Genomics14: 155-160. PMID:24048810
Stark, J.L., Copeland, J.C., Eletsky, A., Somerville, G.A., Szyperski, T., Powers, R. (2014) Identification of Low-molecular-weight Compounds Inhibiting Growth of Corynebacteria: Potential Lead Compounds for Anitibiotics. ChemMedChem9:282-285. PMID:24403054
Muppidi, A., Doi, K., Edwardraja, S., Pulavarti, S.V., Szyperski, T., Wang, H.G., Lin, Q. (2014) Targeted Delivery of Ubiquitin-conjugated BH3 Peptide-based Mcl-1 Inhibitors into Cancer Cells. Bioconj. Chem.24:424-432. PMID:24410055
Sathyamoorthy, B., Parish, D.M., Montelione, G.T., Xiao, R., Szyperski, T. (2014) Spatially Selective Heteronuclear Multiple-quantum (HMQC) Spectroscopy for Bio-molecular Studies. ChemPhysChem15:1872-1879. PMID:24789578.
Liu, G., Poppe, L., Aoki, K., Yamane, H., Lewis, J., Szyperski, T. (2014) High-quality NMR Structure of Human Anti-apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design. PLoS One9:e96521. PMID:24789074
Xu, X., Pulavarti, S.V., Eletsky, A., Huang, Y.J., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Szyperski, T. (2014) Solution NMR Structures of Homeodomains from Human Proteins ALX4, ZHX1, and CASP8AP2 Contribute the Structural Coverage of the Human Cancer Protein Interaction Network. J. Struct. Funct. Genomics15: 201-207. PMID:24941917
Pulavarti, S.V., Huang, Y.P., Pederson, K., Acton, T.B., Xiao, R. Everett, J.K., Prestegard, J.H., Montelione, G.T., Szyperski, T. (2014) Solution NMR Structures of Immunoglobulin-like Domains 7 and 12 from Obscurin-like Protein 1 Contribute the Structural Coverage of the Human Cancer Protein Interaction Network. J. Struct. Funct. Genomics15: 209-214. PMID:24989974
Eletsky, A., Michalska, K., Houliston, S., Zhang, Q., Daily, M.D., Xu, X., Cui, H., Yee, A., Lemak, A, Wu, B., Garcia, M., Burnet, M.C., Meyer, K.M., Aryal, U.K., Sanchez, O., Ansong, C., Xiao, R., Acton, T.B., Adkins, J.N., Montelione, G.T., Joachimiak, A., Arrowsmith, C.H., Savchenko, A., Szyperski, T., Cort, J.R. (2014) Structural and Functional Characterization of DUF1471 Domains of Salmonella Proteins SrfN, YdgH/SssB, and YahO. PloS One9:e1010787.
Pulavarti, S.V., Eletsky, A., Huang, Y.J., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Szyperski, T. (2015) Polypeptide Backbone, Cb and Methyl Group Resonance Assignments of the 24 kDa Plectin Repeat Domain 6 from Human Protein Plectin. J. Biomol. NMR Assign. 9:135-138. PMID: 24722902
Murphy, G.S., Sathyaoorthy, B., Der, B.S., Machius, M.C., Pulavarti, S.V., Szyperski, T., Kuhlman, B. (2015) Computational de novo Design of a Four-helix Bundle Protein-DND_4HB. Protein Sci.24:434-445. PMID:25287625
Everett, J., Tejero, R., Murthy, S.B., Acton, T.B., Aramini, J.M., Baran, M.C., Benach, J., Cort, J.R., Eletsky, A., Forouhar, F., Guan, R., Kuzin, A.P., Lee, H.W., Liu, G., Mani, R., Mao, B., Mills, J.L., Montelione, A.F., Pederson, K., Powers, R., Ramelot, T., Rossi, P., Seetharaman, J., Snyder, D., Swappna, G.V., Vorobiev, S.M., Wu, Y., Xiao, R., Yang. Y. Arrowsmith, C.H., Hunt, J., Kennedy, M.A., Prestegard, J.H., Szyperski, T., Tong, L., Montelione, G.T. (2016) A Community Resource of Experimental Data for NMR-X-ray Crystal Structure Pairs. Protein Sci.25:30-45. PMID 26293815
Wu, X., Liu, R., Sathyamoorthy, B., Yamato, K., Liang, G., Shen, L., Ma, S., Sukumaran, D.K., Szyperski, T., Fang, W., He, L., Chen, X., Gong, B. (2015) Discrete Stacking of Aromatic Oligoamide Macrocycles. J. Am. Chem. Soc. 137:5879-5882. PMID:25909625
Eletsky, A., Pulavarti, S.V., Beaumont, V., Gollnick, P., Szyperski, T. (2015) Solution NMR Experiment for Measurement of 15N-1H Residual Dipolar Couplings in Large Proteins and Supramolecular Complexes. J. Am. Chem. Soc. 137:11242-11245. PMID:26293598
Turkoglu, O., Zeb, A., Graham, S., Szyperski, T., Szender, J. B., Odunsi, K., Szyperski, T., Bahado-Singh, R. (2016) Metabolomics of Biomarker discovery in Ovarian Cancer: a Systematic Review of the Current Literature. Metabolomics12: 60.
Connor, A. L., Hu, T., Detchou, C. S., Liu, R., Pulavarti, S. V., Szyperski, T., Lu, Z., Gong, B. (2016) Aromatic Oligoureas as Hosts for Anions and Cations. Chem. Commun.52: 9905-9908. PMID: 27427283
Jacobs, T. M., Williams, B., Williams, T., Xu, X., Eletsky, A., Federizon, J. F., Szyperski, T., Kuhlman, B. (2016) Design of Structurally Distinct Proteins Using Strategies Inspired by Evolution. Science352: 687-690. PMID: 27151863
Bhardwaj, G., Mulligan, V. K., Bahl, C. D., Gilmore, J. M., Harvey, P. J., Cheneval, O., Buchko, G. W., Pulavarti, S. V., Kaas, Q., Eletsky, A., Huang, P. S., Johnson, W. A., Greisen, P. J., Rocklin, G. J., Song, Y., Linsky, T. W., Watkins, A., Rettie, S. A., Xu, X., Carter, L. P., Bonneau, R., Olson, J. M., Coutsias, E., Correnti, C. E., Szyperski, T., Craik, D. J., Baker, D. (2016) Accurate de Novo Design of Hyperstable Constrained Peptides. Nature538: 329-335. PMID:27626386
Szyperski, T. (2017) Preview: Room Temperature X-Ray Crystallography Reveals Conformational Heterogeneity of Engineered Proteins. Structure25: 691-692. PMID:28467914
Zhang, M., Yu, X.W., Xu, Y., Jouhten, P., Swapna, G.V.T., Glaser, R.W., Hunt, J.F., Montelione, G.T., Maaheimo, H., Szyperski T. (2017) 13C Metabolic Flux Profiling of Pichia pastoris Grown in Aerobic Batch Cultures on Glucose Revealed High Relative Anabolic Use of TCA Cycle and Limited Incorporation of Provided Precursors of Branched-chain Amino Acids. FEBS J: 284: 3100-3113. PMID:28731268
Nie, Y., Wang, S., Xu, Y, Luo, S., Zhao, Y., Xiao, R., Montelione, G.T., Hunt, J.F., Szyperski, T. (2018) Enzyme Engineering Based on X-ray Structures and Kinetic Profiling of Substrate Libraries: Alcohol Dehydrogenases for Stereospecific Synthesis of a Broad Range of Chiral Alcohols. ACS Catal.: 8, 5145-5152.
Buchko, G.W., Pulavarti, S.V.S.R.K., Ovchinnikov, V., Shaw, E.A., Rettie, S.A., Myler, P.J., Karplus, M., Szyperski, T., Baker, D., Bahl, C.D. (2018) Cytosolic Expression, Solution Structures, and Molecular Dynamics Simulation of Genetically Encodable Disulfide-rich De Novo Designed Peptides. Protein Sci.: 27: 1611-1623. PMID: 3015254
Rosarion-Cruz, Z., Eletsky, A., Daigham, N.S., Al-Tameemi, H., Swapna, G.V.T., Kahn, P.C., Szyperski, T., Montelione, G.T., Boyd, J.M. (2019) The copBL Operon Protects Staphylococcus aureus from copper toxicity: CopL is an Extracellular Membrane-associated Copper-binding Protein. J. Biol. Chem.294: 4027-4044.
Zhang Y, Zhong Y, Connor A.L., Miller D.P., Cao R., Shen J., Song B., Baker E.S., Tang Q., Pulavarti S.V.S.R.K., Liu R., Wang Q., Lu Z.L., Szyperski T., Zeng H., Li X., Smith R.D., Zurek E., Zhu J., Gong B. (2019) Folding and Assembly of Short a, b, g-Hybrid Peptides: Minor Variations in Sequence and Drastic Differences in Higher-Level Structures. J. Am. Chem. Soc.141:14239-14248. PMID:31381
Zhang M., Yu X.W., Xu Y., Guo R.T., Swapna G.V.T., Szyperski T., Hunt J.F., Montelione G.T. (2019) Structural Basis by Which the N-Terminal Polypeptide Segment of Rhizopus chinensis Lipase Regulates Its Substrate Binding Affinity. Biochemistry58: 3943-3954. PMID: 31436959
Alvarado C., Stahl E., Koessel K., Rivera A., Cherry B.R., Pulavarti S.V.S.R.K., Szyperski T., Cance W., Marlowe T. (2019) Development of a Fragment-based Screening Assay for the Focal Adhesion Targeting Domain Using SPR and NMR. Molecules24: E3352. PMID:31540099
Wang, X., Jing, X., Deng, Y, Nie, Y., Xu, F., Xu, Y., Zhao, Y.L., Hunt, J.F., Montelione, G.T., Szyperski, T. (2020) Evolutionary Coupling Saturation Mutagenesis: Coevolution-guided Identification of Distant Sites Influencing Bacillus Naganoensis Pullulanase Activity. FEBS Lett.594: 799-812. PMID:31665817
Maguire, J.B., Haddox, H.K., Strickland, D., Halabiya, S.F., Coventry, B., Griffin, J.R., Pulavarti, S.V.S.R.K., Cummins, M., Thieker, D.F., Klavins, E., Szyperski, T., DiMaio, F., Baker, D., Kuhlman, B. (2021) Perturbing the Energy Landscape for Improved Packing During Computational Protein Design. Proteins89:436-449. PMID:33249652
Pulavarti S.V.S.R.K, Maguire, J.B., Yuen, S., Harrison, J.S., Griffin, J., Premkumar, L., Esposito, E.A., Makhatadze, G.I., Garcia, A.E., Weiss, T.M., Snell, E.H., Kuhlman B., Szyperski T. (2022) From Protein Design to the Energy Landscape of a Cold Unfolding Protein. J Phys Chem B126:1212-1231. PMID: 35128921
Li, Y., Zhang, R., Wang, C., Forouhar, F., Clarke, O., Vorobiev, S., Singh, S., Montelione, G.T., Szyperski, T., Xu, Y., Hunt, J.F. (2022) Oligomeric Interactions Maintain Active-site Structure in a Non-cooperative Enzyme Family. EMBO J. 41:e108368. PMID: 358011308.
Szyperski, T. (2022) Teaching NMR Based on the Postulates of Quantum Mechanics Makes This EASY and Relates Theory and Experiment to the Measurement Problem: The NMR Product Operator Rules. J Phys Chem A126:8369-8371. PMID: 36801308
Guffy, S.L., Pulavarti S.V.S.R.K, Harrison, J., Fleming, D., Szyperski, T., Kuhlman, B. (2022) Inside-out Design of Zinc Binding Proteins with Non-native Backbones. Biochemistry, in press.