October 2022: Devin Angevine

Devin Angevine, 5th year PhD student in Prof. Benedict's group

• Angevine, D. J.;  Camacho, K. J.;  Rzayev, J.; Benedict, J. B., Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic Acid. Molecules 2022, 27 (20), 6853. https://doi.org/10.3390/molecules27206853
•  Angevine, D. J.;  Camacho, K. J.;  Rzayev, J.; Benedict, J. B., Transforming liquid nicotine into a stable solid through crystallization with orotic acid. CrystEngComm 2022 (Invited Manuscript). https://doi.org/10.1039/D2CE00764A
• Angevine, D. J.; Benedict, J. B., 4,4'-(Ethene-1,2-diyl)dipyridinium bis(2-hydroxy-3-methoxybenzoate). IUCrData 2022, 7 (5), x220510.https://doi.org/10.1107/S2414314622005107
  
• Angevine, D. J.; Benedict, J. B., The crystal structure of 4,4′-bipyridinium bis-(2-hydroxy-3-methoxybenzoate), 2(C₈H_7.68O₄)·C₁₀H_8.64N₂. Zeitschrift für Kristallographie - New Crystal Structures 2022. https://doi.org/10.1515/ncrs-2022-0126
  
• Angevine, D. J.; Benedict, J. B., 1,2-Bis(pyridin-4-yl)ethene-4-hydroxy-3-methoxybenzoic acid (1/1). IUCrData 2022, 7 (3), x220304. https://doi.org/10.1107/S2414314622003042
  
• Angevine, D. J.; Benedict, J. B., The co-crystal structure of 4-hydroxy-3-methoxybenzoic acid – 4,4′-bipyridine, C₈H₈O₄·C₁₀H₈N₂. Zeitschrift für Kristallographie - New Crystal Structures 2022. https://doi.org/10.1515/ncrs-2022-0088
  
• Angevine, D. J.;  Camacho, K. J.;  Rzayev, J.; Benedict, J. B., Nicotine Refined: Crystal Engineering of (S)-Nicotinium Malate Salts. Crystal Growth & Design 2022, 22 (3), 1594-1603. https://doi.org/10.1021/acs.cgd.1c01110
  
• Benedict, J. B.; Angevine, D. J. Nicotine materials, methods of making same, and uses thereof. WO2021126313A1, June 2021. https://patents.google.com/patent/WO2021126313A1
  

My research centers around the utilization of crystal engineering to transform the notorious active pharmaceutical ingredient nicotine into a safer, more stable and tunable solid-state material through the use of US FDA generally recognized as safe (GRAS) substances. By crystallizing liquid nicotine with GRAS listed components and engineering these materials to safely degrade, we are able to eliminate the current pitfalls associated with nicotine products and deliver a safer and tunable material to the end user.

The close friendships, comradery, and supportive environment from my PI has made UB a place of great academic and scientific growth.

Outside of the lab I enjoy hiking and exploring nature with family or friends.