Graduate Research Highlights
Ming Fang
PhD student in Dr. Lin's lab.
I am interested in researching the development and application of bioorthogonal reagents, particularly hydrazonyl sultones, which are stable tautomers of nitrile imines. My focus is on using these reagents for selective protein modifications in both solutions and live cells to answer biological questions.
I enjoy being a graduate student at UB because of the diverse research opportunities it offers and the supportive academic community that fosters growth and innovation.
Outside of the lab, I love hiking in nature, exploring local cafes, and immersing myself in a good book.
M. Fang, G.S. Kumar, S. Racioppi, H. Zhang, J.D. Rabb, E. Zurek, Q. Lin, "Hydrazonyl Sultones as Stable Tautomers of Highly Reactive Nitrile Imines for Fast Bioorthogonal Ligation Reaction", J. Am. Chem. Soc. 2023, 145(18), 9959. Article link: https://doi.org/10.1021/jacs.2c12325
M. Fang, G.S. Kumar, Q. Lin, "Systematic Structural Tuning Yields Hydrazonyl Sultones for Faster Bioorthogonal Protein Modification", ChemBioChem, 2023, 24, e202300398. Article link: https://doi.org/10.1002/cbic.202300398
T.M. Lewandowski, P. An, C.P. Ramil, M. Fang, Q. Lin, "Dual Fluorescent Labelling of GLP-1R in Live Cells via Enzymatic Tagging and Bioorthogonal Chemistry", RSC Chem. Biol., 2022, 3, 702. Article link: https://doi.org/10.1039/D2CB00107A
Y. Tian, M. Fang, Q. Lin, "Intracellular Bioorthogonal Labeling of Glucagon Receptor via Tetrazine Ligation", Bioorg. Med. Chem., 2021, 43, 116256. Article link: https://doi.org/10.1016/j.bmc.2021.116256